抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Annual review of condensed matter physics

Journal of Physics Condensed Matter: Preface

Journal of Physics A - Mathematical and General, Special Issue. SI Aug 11 2006 ?? Preface

Active matter, which ranges from molecular motors to groups of animals, exists at different length scales and timescales, and various computational models have been proposed to describe and predict its behaviour. The diversity of the methods and the challenges in modelling active matter primarily originate from the out-of-equilibrium character, lack of detailed balance and of time-reversal symmetry, multiscale nature, nonlinearity and multibody interactions. Models exist for both dry active matter and active matter in fluids, and can be agent-based or continuum-level descriptions. They can be generic, emphasizing universal features, or detailed, capturing specific features. We compare various modelling approaches and numerical techniques to illuminate the innovations and challenges in understanding active matter. Active matter consists of energy-consuming units, which self-propel, exert forces on their neighbours and act collectively, resulting in emergent non-equilibrium behaviour. This Review surveys computational models that describe a wide range of active systems, from synthetic microswimmers to animal herds.

Computational models for active matter

Vibrated polar disks have been used experimentally to investigate collective motion of driven particles, where fully ordered asymptotic regimes could not be reached. Here we present a model reproducing quantitatively the single, binary, and collective properties of this granular system. Using system sizes not accessible in the laboratory, we show in silico that true long-range order is possible in the experimental system. Exploring the model's parameter space, we find a phase diagram qualitatively different from that of dilute or pointlike particle systems.

/pdf/long-range-ordering-of-vibrated-polar-disks-4xcb22xpov.pdf

Long-Range Ordering of Vibrated Polar Disks

Collective motion in actively propelled particle systems is triggered on the very local scale by nucleation of coherently moving units consisting of just a handful of particles. These units grow and merge over time, ending up in a long-range ordered, coherently moving state. So far, there exists no bottom-up understanding of how the microscopic dynamics and interactions between the constituents are related to the system's ordering instability. In this paper, we study a class of models for propelled colloids allowing an explicit treatment of the microscopic details of the collision process. Specifically, the model equations are Newtonian equations of motion with separate force terms for particles' driving, dissipation, and interaction forces. Focusing on dilute particle systems, we analyze the binary scattering behavior for these models and determine---based on the microscopic dynamics---the corresponding ``collision rule,'' i.e., the mapping of precollisional velocities and impact parameter on postcollisional velocities. By studying binary scattering we also find that the considered models for active colloids share the same principle for parallel alignment: The first incoming particle (with respect to the center of collision) is aligned to the second particle as a result of the encounter. This behavior distinctively differs from alignment in nondriven dissipative gases. Moreover, the obtained collision rule lends itself as a starting point to apply kinetic theory for propelled particle systems in order to determine the phase boundary to a long-range ordered, coherently moving state. The microscopic origin of the collision rule offers the opportunity to quantitatively scrutinize the predictions of kinetic theory for propelled particle systems through direct comparison with multiparticle simulations. We identify local precursor correlations at the onset of collective motion to constitute the essential determinant for a qualitative and quantitative validity of kinetic theory. In conclusion, our ``renormalized'' approach clearly indicates that the framework of kinetic theory is flexible enough to accommodate the complex behavior of soft active colloids and allows a bottom-up understanding of how the microscopic dynamics of binary collisions relates to the system's behavior on large length and time scales.

Understanding collective dynamics of soft active colloids by binary scattering.

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Long-Range Ordering of Vibrated Polar Disks

Understanding collective dynamics of soft active colloids by binary scattering.