Timm Graening
University of Cologne
18 Papers
177 Citations
Timm Graening is an academic researcher from University of Cologne. The author has contributed to research in topics: Cladding (metalworking) & Zirconium alloy. The author has an hindex of 7, co-authored 10 publications.
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Papers
Total syntheses of colchicine in comparison: a journey through 50 years of synthetic organic chemistry.
TL;DR: The comparative examination of all known colchicine total syntheses undertaken in this Review not only reveals the tremendous progress in synthetic organic methodology over the past decades, but also shows how the unique synthetic problems posed by this molecule can be solved in an exceptionally creative manner.
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Pd-catalyzed enantioselective allylic substitution: new strategic options for the total synthesis of natural products.
TL;DR: The enantioselective version of palladium-catalyzed allylic substitution, sometimes referred to as AAA (asymmetric allylic alkylation), has emerged as a powerful synthetic tool and has recently proven to be of particular value as they react with cyclic substrates of type 1 and 2.
160
Total synthesis of (-)-colchicine via a Rh-triggered cycloaddition cascade.
TL;DR: A synthesis of the antimitotic alkaloids (-)-colchicine and (-)-isocolchicines is reported, which opens an efficient enantioselective access to colchichine and structural analogues.
97
Colchicin‐Totalsynthesen im Vergleich: eine Reise durch 50 Jahre Organische Synthesechemie
TL;DR: In den letzten Jahren gelungen, Synthesen zu entwickeln, die effizient auch neue, strukturell modifizierte Colchicin-Derivate totalsynthetisch zuganglich machen.
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