Tim Sproul
Bristol-Myers Squibb
8 Papers
47 Citations
Tim Sproul is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: CCR8 & FOXP3. The author has an hindex of 3, co-authored 8 publications. Previous affiliations of Tim Sproul include Princeton University.
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Papers
Fc-Optimized Anti-CCR8 Antibody Depletes Regulatory T Cells in Human Tumor Models.
Joseph R Campbell,Bryan McDonald,Paul B Mesko,Nathan O. Siemers,Priti B. Singh,Mark J. Selby,Tim Sproul,Alan J. Korman,Logan M Vlach,Jeff Houser,Sharmila Sambanthamoorthy,Kai Lu,Sandra V. Hatcher,Jack Lohre,Renu Jain,Ruth Y. Lan +15 more
TL;DR: In this paper, the chemokine receptor CCR8 was proposed as an optimal tumor Treg target and selectively expressed on suppressive tumor T cells and minimally expressed on proinflammatory effector T cells (Teff).
95
Patent
Human antibodies that bind cd22 and uses thereof
David John King,Alison Witte,Heidi N. Leblanc,Richard Theolis,Asna Masood,Mark Yamanaka,Kyra D. Zens,Dwiggins Sara R,Tim Sproul,Chetana Rao-Naik,David Passmore,Kristopher Toy,Dawn M. Tanamachi +12 more
- 30 Nov 2007
TL;DR: In this article, isolated monoclonal antibodies that specifically bind to CD22 with high affinity are provided, and methods for expressing the antibodies of this disclosure are also provided, as well as methods for treating various cancers and inflammatory and autoimmune disorders using an anti-CD22 antibody.
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Design and characterization of mouse IgG1 and IgG2a bispecific antibodies for use in syngeneic models
Feng Wang,Jordan C Tsai,Jonathan H Davis,Bryant Chau,Jia Dong,Sean M. West,Jason M. Hogan,Matthew L. Wheeler,Christine Bee,Winse Morishige,Thomas Cayton,Donata David-brown,Chengyue Zhang,Alexander T. Kozhich,Tim Sproul,Gavin Dollinger,Arvind Rajpal,Pavel Strop +17 more
TL;DR: This work engineered a simple co-expression system for one-step purification of intact mouse IgG1 and IgG2a bispecific antibodies from any antibody pair, and demonstrated proof of concept with CD3/CD20 bispespecific antibodies, which highlighted both the quality and efficacy of materials generated by this technology.
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Abstract 6694: Highly selective anti-CCR8 antibody-mediated depletion of regulatory T cells leads to potent antitumor activity alone and in combination with anti-PD-1 in preclinical models
Ruth Y. Lan,Amy Jhatakia,Joseph R Campbell,Nathan O. Siemers,Kai Lu,Mohammed Nasser,Tetiana Grigoriev,Priti B. Singh,Logan M Vlach,Tim Sproul,Chengyue Zhang,Xi-Tao Wang,Olufemi Adelakun,Felix Findeisen,Pavel Strop,Arvind Rajpal,Natalie Bezman,Michael Quigley,Renu Jain +18 more
TL;DR: The results support further clinical evaluation of CCR8 depletion in combination with immune checkpoint blockade as a novel immunotherapy for cancer.
4
Patent
Anticorps humains se liant à cd22 et utilisations de ceux-ci
David John King,Alison Witte,Heidi N. Leblanc,Richard Theolis,Asna Masood,Mark Yamanaka,Kyra D. Zens,Sara R. Dwiggins,Tim Sproul,Chetana Rao-Naik,David Passmore,Kristopher Toy,Dawn M. Tanamachi +12 more
- 30 Nov 2007
TL;DR: In this paper, the authors propose egalement des molecules d'acide nucleique codant les anticorps de cette revelation, des vecteurs d'expression, des cellules hotes and des procedes pour exprimer les anticorsps de this revelation.