Tim Söderlund
University of Helsinki
33 Papers
308 Citations
Tim Söderlund is an academic researcher from University of Helsinki. The author has contributed to research in topics: Blunt trauma & Injury Severity Score. The author has an hindex of 16, co-authored 33 publications. Previous affiliations of Tim Söderlund include Helsinki University Central Hospital.
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Papers
Comparison of the Effects of Surface Tension and Osmotic Pressure on the Interfacial Hydration of a Fluid Phospholipid Bilayer
TL;DR: Surface tension is suggested to determine the impact of these solutes on the lateral packing of the lipid bilayer based on the changes in area/lipid at different surface tensions.
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Interactions of cyclosporin A with phospholipid membranes: effect of cholesterol.
TL;DR: CsA altered the distribution of 1-palmitoyl-2-(N-4-nitrobenz-2-oxa-1, 3-diazol)aminocaproyl-phosphocholine in a dipalmitoyslphosphatidylcholine film and in DPPC/beta-cholesterol mixtures in a manner that suggests that CsA partitions into the boundaries between fluid and gel domains.
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Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
TL;DR: The surface activity profiles are shown to correlate to the ability of the compounds to pass passively through the blood-brain barrier, and provide precise thermodynamic information on the partitioning behavior of molecules at air/water interfaces.
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•Journal Article
Binding of novel peptide inhibitors of type IV collagenases to phospholipid membranes and use in liposome targeting to tumor cells in vitro.
Oula Penate Medina,Tim Söderlund,Liisa J. Laakkonen,Esa K.J. Tuominen,Erkki Koivunen,Paavo K.J. Kinnunen +5 more
TL;DR: CTT enhanced 3- to 4-fold the cellular uptake of liposome-encapsulated water-soluble fluorescent marker, rhodamine B by gelatinase-expressing cells, and suggests a novel type of utility for small gelatinase inhibitors in targeted cancer therapy.
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Angiographic embolization in the treatment of arterial pelvic hemorrhage: evaluation of prognostic mortality-related factors
TL;DR: PRAF patients with exsanguinating bleeding from the large pelvic artery have the worst prognosis, thus anticipating a poor outcome in bleeding controlled with TAE only and an increased risk of death.