Tim Ragan

TL;DR: It is demonstrated that simple pelleting of exo-AAV from media via ultracentrifugation results in high-titer vector preparations capable of efficient transduction of central nervous system (CNS) cells after systemic injection in mice, and the ability of exosomes to evade neutralizing antibodies while still transducing CNS after peripheral delivery is clinically relevant.

TL;DR: In this paper , a recently developed model of familial Alzheimer's disease (fAD), expressing Swedish, Arctic and Austrian mutations in App (hAbetaSAA), has been shown to be a useful amyloidogenic model which recapitulates many aspects of human AD, including plaque distribution and microglial transcriptional changes.

TL;DR: The APPSAA mouse model is characterized for preclinical Alzheimer's disease research, exhibiting clinically relevant phenotypes throughout aging, making it a useful model for translational research and preclinical testing of therapeutics without licensing restrictions.