Tim R. Geistlinger
Harvard University
5 Papers
101 Citations
Tim R. Geistlinger is an academic researcher from Harvard University. The author has contributed to research in topics: Estrogen receptor alpha & Estrogen receptor beta. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Tim R. Geistlinger include Brigham and Women's Hospital.
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Papers
Estradiol-regulated microRNAs control estradiol response in breast cancer cells
Poornima Bhat-Nakshatri,Guohua Wang,Nikail Collins,Michael J. Thomson,Tim R. Geistlinger,Jason S. Carroll,Myles Brown,Scott M. Hammond,Edward F. Srour,Yunlong Liu,Harikrishna Nakshatri +10 more
TL;DR: It is proposed that the clinical course of ERα-positive breast cancers is dependent on the balance between E2-regulated tumor-suppressor micro RNAs and oncogenic microRNAs, and a negative-regulatory loop controlling E2 response through microRN as well as differences in E1-induced transcriptome and proteome.
A comprehensive view of nuclear receptor cancer cistromes
Qianzi Tang,Yiwen Chen,Clifford A. Meyer,Tim R. Geistlinger,Mathieu Lupien,Qian Wang,Tao Liu,Yong Zhang,Myles Brown,Xiaole Shirley Liu +9 more
TL;DR: This analysis suggests that the binding of ESR1, RARA, and RARG has both activating and repressive effects, and a curated database of 88 nuclear receptor cistrome data sets and other associated high-throughput data sets constitutes a valuable resource for the nuclear receptor and cancer community.
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AKT Alters Genome-Wide Estrogen Receptor α Binding and Impacts Estrogen Signaling in Breast Cancer
Poornima Bhat-Nakshatri,Guohua Wang,Hitesh Nidumanda Appaiah,Nikhil Luktuke,Jason S. Carroll,Tim R. Geistlinger,Myles Brown,Sunil Badve,Yunlong Liu,Harikrishna Nakshatri +9 more
TL;DR: A unique role of AKT in modulating estrogen signaling in ERα-positive breast cancers is suggested and how extracellular signal activated kinases can change the landscape of transcription factor binding to the genome is highlighted.
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Subcellular Localization of Activated AKT in Estrogen Receptor- and Progesterone Receptor-Expressing Breast Cancers : Potential Clinical Implications
Sunil Badve,Nikail Collins,Poornima Bhat-Nakshatri,Dmitry Turbin,Samuel Leung,Mangesh A. Thorat,Sandra E. Dunn,Tim R. Geistlinger,Jason S. Carroll,Myles Brown,Shikha Bose,Michael A. Teitell,Harikrishna Nakshatri +12 more
TL;DR: It is suggested that subcellular localization of activated AKT plays a significant role in determining its function in breast cancer, which in part is dependent on TCL1B expression.
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Interplay between estrogen receptor and AKT in Estradiol-induced alternative splicing
Poornima Bhat-Nakshatri,Eun Kyung Song,Nikail Collins,Vladimir N. Uversky,Vladimir N. Uversky,A. Keith Dunker,Bert W. O'Malley,Tim R. Geistlinger,Jason S. Carroll,Jason S. Carroll,Myles Brown,Harikrishna Nakshatri +11 more
TL;DR: E2 may partly alter cellular proteome through alternative splicing uncoupled to its effects on transcription initiation and aberration in E2-inducedAlternative splicing events may influence response to anti-estrogens.