Tim McCubbin
University of Queensland
16 Papers
2 Citations
Tim McCubbin is an academic researcher from University of Queensland. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 4, co-authored 6 publications.
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Papers
Microbial Propionic Acid Production
R. Axayacatl Gonzalez-Garcia,Tim McCubbin,Laura Navone,Chris C. Stowers,Lars K. Nielsen,Esteban Marcellin +5 more
TL;DR: The current review provides an in-depth description of the major metabolic routes for propionate production from an energy optimization perspective and suggests ways in which the target yield, productivity and titre can be achieved.
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Dysregulated energy metabolism impairs chondrocyte function in osteoarthritis.
Xiao-Xuan Wu,Chamikara Liyanage,Manuel R. Plan,Terra Stark,Tim McCubbin,Roberto A. Barrero,Jyotsna Batra,Ross Crawford,Yin Xiao,Indira Prasadam +9 more
TL;DR: In this article , the effects of low-dose and short-term effects of 2-deoxyglucose (2DG) on chondrocytes were investigated.
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A Pan-Genome Guided Metabolic Network Reconstruction of Five Propionibacterium Species Reveals Extensive Metabolic Diversity.
Tim McCubbin,R. Axayacatl Gonzalez-Garcia,Robin W. Palfreyman,Chris C. Stowers,Lars K. Nielsen,Esteban Marcellin +5 more
TL;DR: Pan-genome analysis combined with the reconstruction of the first high-quality Propionibacterium genome-scale metabolic model and a pan-metabolic model of current and former members of the genus PropionIBacterium demonstrated that these organisms have an unexpected diversity in central carbon metabolism and a hidden layer of metabolic complexity.
Awakening sleeping beauty: production of propionic acid in Escherichia coli through the sbm operon requires the activity of a methylmalonyl-CoA epimerase
R. A. Gonzalez-Garcia,Tim McCubbin,Annalena Wille,Manuel R. Plan,Lars K. Nielsen,Esteban Marcellin +5 more
TL;DR: The engineered pathway was shown to be functional under anaerobic and aerobic conditions and production of propionic acid from glucose as sole carbon source is possible when the pathway is complemented with a methylmalonyl-CoA epimerase.
Genome-scale model guided design of Propionibacterium for enhanced propionic acid production
TL;DR: Together, these strategies demonstrate that in silico design strategies are predictive and can be used to reduce by-product formation in Propionibacterium.
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