Tim Kroon
VU University Amsterdam
15 Papers
55 Citations
Tim Kroon is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Neurotransmission & Cholinergic. The author has an hindex of 10, co-authored 15 publications. Previous affiliations of Tim Kroon include King's College London.
Chat about Author
Papers
Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits.
Emilia Favuzzi,Emilia Favuzzi,Rubén Deogracias,Rubén Deogracias,Andre Marques-Smith,Patricia Maeso,Patricia Maeso,Julie Jézéquel,David Exposito-Alonso,Maddalena Balia,Tim Kroon,Antonio Jesús Hinojosa,Antonio Jesús Hinojosa,Elisa F. Maraver,Beatriz Rico,Beatriz Rico +15 more
TL;DR: Whether interneurons form synapses on the dendrites, soma, or axon initial segment of pyramidal cells is determined by synaptic molecules that are expressed in a subtype-specific manner, indicating that cell-specific molecular programs that unfold during early postnatal development underlie the connectivity patterns of cortical interneuronons.
Early postnatal development of pyramidal neurons across layers of the mouse medial prefrontal cortex.
Tim Kroon,Tim Kroon,Eline van Hugte,Eline van Hugte,Lola A. van Linge,Huibert D. Mansvelder,Rhiannon M. Meredith +6 more
TL;DR: The characterisation of the early development and maturation of pyramidal neurons in mouse mPFC demonstrates a comparable time course of postnatal maturation to that in other neocortical circuits, and implies that consideration of layer- and time-specific changes in pyramid neurons may be relevant for studies in mouse models of neuropsychiatric and neurodevelopmental disorders.
Lateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex
Joshua Obermayer,Tim S. Heistek,Amber Kerkhofs,Natalia A. Goriounova,Tim Kroon,Tim Kroon,Johannes C. Baayen,Sander Idema,Guilherme Testa-Silva,Guilherme Testa-Silva,Jonathan J. Couey,Jonathan J. Couey,Huibert D. Mansvelder +12 more
TL;DR: It is found that cholinergic inputs selectively augment and speed up lateral inhibition between pyramidal neurons mediated by MCs, but not by BCs, and that these mechanisms are conserved in human neocortex.
Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention
Joshua Obermayer,Antonio Luchicchi,Tim S. Heistek,Sybren F. de Kloet,Huub Terra,Bastiaan Bruinsma,Ouissame Mnie-Filali,Christian Kortleven,Anna A. Galakhova,Ayoub J. Khalil,Tim Kroon,Tim Kroon,Allert J. Jonker,Roel de Haan,Wilma D.J. van den Berg,Natalia A. Goriounova,Christiaan P. J. de Kock,Tommy Pattij,Huibert D. Mansvelder +18 more
TL;DR: It is reported that ChAT-VIP subtype of interneurons directly excite pyramidal neurons in multiple layers via fast cholinergic neurotransmission and they control attention behaviour distinctly from basal forebrain ACh inputs.
Investigating mechanisms underlying neurodevelopmental phenotypes of autistic and intellectual disability disorders: a perspective.
TL;DR: This approach may help explain why many NDDs with differing genetic causes can result in overlapping phenotypes at similar developmental stages and better predict vulnerable periods within these disorders, with implications for both therapeutic rescue and ultimately, prevention.