Tim J. Schulz
University of Potsdam
10 Papers
2 Citations
Tim J. Schulz is an academic researcher from University of Potsdam. The author has contributed to research in topics: White adipose tissue & Brown adipose tissue. The author has an hindex of 3, co-authored 10 publications.
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Papers
Identification of functional lipid metabolism biomarkers of brown adipose tissue aging.
Sabrina Gohlke,Vyacheslav Zagoriy,Alvaro Cuadros Inostroza,Michaël Méret,Carola Mancini,Lukasz Japtok,Fabian Schumacher,Doreen Kuhlow,Antonia Graja,Heike Stephanowitz,Markus Jähnert,Eberhard Krause,Andreas Wernitz,Klaus-Jürgen Petzke,Annette Schürmann,Burkhard Kleuser,Tim J. Schulz +16 more
TL;DR: Functional analyses show that changes in specific lipid species, as observed during aging, may contribute to reduced thermogenic potential, thereby providing potential treatment strategies of age-related metabolic conditions.
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Loss of periostin occurs in aging adipose tissue of mice and its genetic ablation impairs adipose tissue lipid metabolism.
Antonia Graja,Francisco Garcia-Carrizo,Anne-Marie Jank,Sabrina Gohlke,Thomas H. Ambrosi,Wenke Jonas,Siegfried Ussar,Matthias Kern,Annette Schürmann,Krasimira Aleksandrova,Matthias Blüher,Tim J. Schulz +11 more
TL;DR: The data suggest that loss of periostin attenuates lipid metabolism in adipose tissue, thus recapitulating one aspect of age‐related metabolic dysfunction, which may contribute to the development of metabolic disease by negatively affecting nutrient homeostasis.
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Identification of biomarkers of brown adipose tissue aging highlights the role of dysfunctional energy and nucleotide metabolism pathways.
Carola Mancini,Sabrina Gohlke,Francisco Garcia-Carrizo,Vyacheslav Zagoriy,Heike Stephanowitz,Tim J. Schulz +5 more
TL;DR: In this article, an analysis of interscapular brown adipose tissue samples from young and aged mice for quantification of differential gene expression and metabolite levels was carried out to identify potential processes involved in brown adipocyte dysfunction.
Wt1 haploinsufficiency induces browning of epididymal fat and alleviates metabolic dysfunction in mice on high-fat diet
Karin M. Kirschner,Anna Foryst-Ludwig,Anna Foryst-Ludwig,Sabrina Gohlke,Chen Li,Roberto E. Flores,Ulrich Kintscher,Ulrich Kintscher,Michael Schupp,Tim J. Schulz,Holger Scholz +10 more
TL;DR: In this paper, the authors investigated the hypothesis that the Wilms tumour gene product (WT1), which is expressed in intra-abdominal WAT but not in subcutaneous WAT and BAT, suppresses a thermogenic program in white fat cells.
Loss of the ciliary gene Bbs4 results in defective thermogenesis due to metabolic inefficiency and impaired lipid metabolism
TL;DR: In this paper, the effects of a functional BBSome on energy metabolism and lipid mobilization in brown and white adipocytes were tested in whole-body Bbs4 knockout mice that were subjected to metabolic challenges.
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