Tim Doyle
Royal Sussex County Hospital
5 Papers
3 Citations
Tim Doyle is an academic researcher from Royal Sussex County Hospital. The author has contributed to research in topics: TSC1 & Tuberous sclerosis. The author has an hindex of 3, co-authored 5 publications.
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Papers
Sirolimus therapy for angiomyolipoma in tuberous sclerosis and sporadic lymphangioleiomyomatosis: a phase 2 trial.
D. Mark Davies,Petrus J. de Vries,Simon R. Johnson,Deborah L. McCartney,Deborah L. McCartney,J. Cox,Andreas L. Serra,Peter Watson,Christopher J. Howe,Tim Doyle,Kate Pointon,Justin J. Cross,Anne E. Tattersfield,J. Chris Kingswood,Julian R. Sampson +14 more
TL;DR: This study showed sustained regression of renal angiomyolipomas in patients with tuberous sclerosis or sporadic LAM receiving 2 years of sirolimus treatment, suggesting possible effects on pulmonary function and neurocognition require further investigation.
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Sirolimus therapy in tuberous sclerosis or sporadic lymphangioleiomyomatosis.
D. Mark Davies,Simon R. Johnson,Anne E. Tattersfield,J. Chris Kingswood,J. Cox,Deborah L. McCartney,Tim Doyle,Frances Elmslie,Anand Saggar,Petrus J. de Vries,Julian R. Sampson +10 more
TL;DR: Constitutive activation of mTOR and its downstream targets occurs in lesions associated with tuberous sclerosis or lymphangioleiomyomatosis, suggesting that mTOR .
216
Outbreak of Listeriosis in South Africa Associated with Processed Meat.
Juno Thomas,N. Govender,Kerrigan McCarthy,Linda Erasmus,Tim Doyle,Mushal Allam,Arshad Ismail,Ntsieni Ramalwa,Phuti Sekwadi,Genevie Ntshoe,A.M. Shonhiwa,Vivien Essel,Nomsa P. Tau,Shannon L. Smouse,Hlengiwe M Ngomane,Bolele Disenyeng,Nicola Page,Nelesh P. Govender,Adriano Duse,Robert W. Stewart,Teena Thomas,Deon Mahoney,Mathieu Tourdjman,Olivier Disson,Pierre Thouvenot,Mylène M. Maury,Alexandre Leclercq,Marc Lecuit,Anthony M. Smith,Lucille Blumberg +29 more
TL;DR: This investigation showed that in a middle-income country with a high prevalence of HIV infection, L. monocytogenes caused disproportionate illness among pregnant girls and women and HIV-infected persons.
197
0.5 Tesla cine-magnetic resonance angiography is a poor screening test for atheromatous renal artery stenosis in chronic renal failure
TL;DR: It is concluded that 0.5 Tesla MRA has only limited usefulness as a non‐invasive screening test for ARAS, demonstrating fair sensitivity, comparable to other screening methods, in the context of significant renal impairment, however, specificity was poor.
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