Tim Axtelle
Icos
9 Papers
60 Citations
Tim Axtelle is an academic researcher from Icos. The author has contributed to research in topics: CD14 & Cytokine. The author has an hindex of 7, co-authored 9 publications.
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Papers
IC14, an Anti-CD14 Antibody, Inhibits Endotoxin-Mediated Symptoms and Inflammatory Responses in Humans
Annelies Verbon,Pascale E. P. Dekkers,T. Ten Hove,C. E. Hack,John Pribble,Terence Turner,Sonia Souza,Tim Axtelle,Frans J. Hoek,S. J. H. Van Deventer,T. van der Poll +10 more
TL;DR: Data provide the first proof of principle that blockade of CD14 is associated with reduced LPS responsiveness in humans in vivo, and strongly inhibited LPS-induced proinflammatory cytokine release, while only delaying the release of the anti-inflammatory cytokines soluble TNF receptor type I and IL-1 receptor antagonist.
CD14 receptor occupancy in severe sepsis: results of a phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14).
Konrad Reinhart,Thomas Glück,Jack J. M. Ligtenberg,Klaus Tschaikowsky,Albert Bruining,Jan Bakker,Steven M. Opal,Lyle L. Moldawer,Tim Axtelle,Terence Turner,Sonia Souza,John Pribble +11 more
TL;DR: The results suggest that CD14 blockade with IC14 warrants further clinical investigation to determine its ability to attenuate the proinflammatory response due to infection.
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Treatment with an Anti-CD14 Monoclonal Antibody Delays and Inhibits Lipopolysaccharide-Induced Gene Expression in Humans in Vivo
C. Arnold Spek,Annelies Verbon,Hella Aberson,John Pribble,Cathal J. McElgunn,Terence Turner,Tim Axtelle,Jan P. Schouten,Tom van der Poll,Pieter H. Reitsma +9 more
TL;DR: Gene expression profiles in blood cells corresponded poorly with observed changes in plasma levels, suggesting that peripheral blood cells are of negligible importance in LPS-induced production of inflammatory mediators in vivo and that LPS may activate genes via a CD14-independent pathway that is slower and less efficient.
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IC14, a CD14 specific monoclonal antibody, is a potential treatment for patients with severe sepsis:
Tim Axtelle,John Pribble +1 more
TL;DR: In rabbits and non-human primates, CD14 specific antibodies were shown to attenuate responses to LPS or Escherichia coli challenge including pro-inflammatory cytokine release, acute lung injury, hypotension and changes in lung, liver, spleen and adrenal gland morphology.
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Effects of IC14, an Anti-CD14 Antibody, on Coagulation and Fibrinolysis during Low-Grade Endotoxemia in Humans
Annelies Verbon,Joost C. M. Meijers,C. Arnold Spek,C. Erik Hack,John Pribble,Terence Turner,Pascale E. P. Dekkers,Tim Axtelle,Marcel Levi,Sander J. H. van Deventer,Pieter H. Reitsma,Tom van der Poll +11 more
TL;DR: The results suggest that different hemostatic responses during endotoxemia may proceed via CD14-dependent and -independent pathways.