Tijmen Keller
5 Papers
Tijmen Keller is an academic researcher. The author has contributed to research in topics: Internal medicine & Heart failure. The author has an hindex of 1, co-authored 1 publications.
Chat about Author
Papers
Ability of Recombinant Factor VIIa to Generate Thrombin During Inhibition of Tissue Factor in Human Subjects
Philip W. Friederich,Marcel Levi,Kenneth A. Bauer,George P. Vlasuk,William E. Rote,Daan Breederveld,Tijmen Keller,Marco Spataro,S Barzegar,Harry R. Büller +9 more
TL;DR: The in vivo potential of recombinant factor VIIa (rVIIa) to induce thrombin generation in healthy subjects pretreated with recombinant nematode anticoagulant protein c2 is investigated, indicating that rVIIa may be a good candidate as an antidote for inhibitors of tissue factor.
88
Impact of inflammatory phenotype on prognostic discrimination for the novel biomarker cellular communication network factor 1 (CCN1) in patients with dilated cardiomyopathy
Roland Klingenberg,Stefan Gross,K Lehnert,Douglas Wegner,Christian W. Hamm,S E Felix,Tijmen Keller,Marcus Doerr +7 more
TL;DR: In this pilot cohort, the inflammatory phenotype had no impact on prognostic discrimination and CCN1 independently predicts all-cause mortality in DCM patients and improves risk stratification beyond the MAGGIC score.
Does a 6-month change in circulating biomarkers improve the prognostic power of baseline values for predicting cardiac MRI pathologies in patients with STEMI?
Frank A. Holtkamp,David Gruen,A. Frey,Valérie Jahns,Roland Jahns,Tobias Gassenmaier,Christian W. Hamm,Sophie Frantz,Tijmen Keller,Roland Klingenberg +9 more
TL;DR: In this paper , the authors compared the predictive power of circulating biomarkers at baseline and their change over time for the development of structural changes typical of heart failure after STEMI using serial measurements of CCN1, ST2, hs-TnT, and NT-proBNP.
The long non-coding RNA Heat4 is dynamically regulated during cardiogenic shock
Matthias Winkler,Jasmin M Kneuer,Tim Meinecke,Maximilian Moebius-winkler,Ronald Weiss,Jan Haas,T. Garfias-Veitl,S. Von Haehling,Tijmen Keller,Holger Thiele,Philipp Lurz,T Speer,Ulrich Laufs,Jes Niels Boeckel +13 more
TL;DR: The lncRNA Heat4 is upregulated in the blood of patients with chronic heart failure, acute myocardial infarction and cardiogenic shock and this regulation was validated in an independent second cohort.
The anti-inflammatory LncRNA Heat4 interacts with the pro-inflammatory protein IP1 in non-classical monocytes promoting vascular regeneration
Jasmin M Kneuer,Matthew M. Winkler,Tim Meinecke,Maximilian N. Möbius-Winkler,Ronald Weiss,J. Haas,Aileen Kogel,K.-P. Kresoja,Sebastian Rosch,Stephan Erbe,Karoline E. Kokot,P. Stürzebecher,T. Garfias-Veitl,S. Von Haehling,Tijmen Keller,Holger Thiele,P. Lurz,T Speer,Ulrich Laufs,Jes Niels Boeckel +19 more
TL;DR: This study identifies the lncRNA Heat4 as an anti-inflammatory mediator in non-classical monocytes, promoting vascular regeneration by interacting with the pro-inflammatory protein IP1, and suggests its potential as a novel therapeutic target for cardiovascular diseases.