Tiffany King
Ohio State University
5 Papers
1 Citations
Tiffany King is an academic researcher from Ohio State University. The author has contributed to research in topics: Infectivity & Coronavirus. The author has an hindex of 4, co-authored 5 publications. Previous affiliations of Tiffany King include Nationwide Children's Hospital.
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Papers
SARS-CoV-2 Spreads through Cell-to-Cell Transmission
Cong Zeng,John P. Evans,Tiffany King,Tiffany King,Yi-Min Zheng,Eugene M. Oltz,Sean P. J. Whelan,Linda J. Saif,Linda J. Saif,Shan-Lu Liu +9 more
TL;DR: Evidence that SARS-CoV-2 spreads through cell-cell contact in cultures, mediated by the spike glycoprotein is provided, with important implications for a better understanding of Sars-Cov-2 spread and pathogenesis.
Mathematical modelling identifies the role of adaptive immunity as a key controller of respiratory syncytial virus in cotton rats
Darren Wethington,Olivia Harder,Karthik Uppulury,William C. L. Stewart,William C. L. Stewart,Phylip Chen,Tiffany King,Tiffany King,Susan D. Reynolds,Susan D. Reynolds,Alan S. Perelson,Mark E. Peeples,Mark E. Peeples,Stefan Niewiesk,Jayajit Das +14 more
TL;DR: The combined approach quantified the importance of the adaptive immune response in suppressing RSV infection in cotton rats, which could be useful in testing RSV vaccine candidates.
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The larger attachment glycoprotein of respiratory syncytial virus produced in primary human bronchial epithelial cultures reduces infectivity for cell lines.
TL;DR: In this paper, the authors found that RSV (HBE) virions were approximately 100-fold more infectious for HBE cultures than for HEp-2 cells and that the cause of this differential infectivity was reduced infectivity of RSV on HEp2 cells rather than enhanced infectivity on HBE culture.
Mathematical Modeling Identifies the Role of Adaptive Immunity as a Key Controller of Respiratory Syncytial Virus (RSV) Titer in Cotton Rats
Darren Wethington,Olivia Harder,Karthik Uppulury,William C. L. Stewart,William C. L. Stewart,Phylip Chen,Phylip Chen,Tiffany King,Tiffany King,Susan D. Reynolds,Susan D. Reynolds,Mark E. Peeples,Mark E. Peeples,Stefan Niewiesk,Jayajit Das +14 more
TL;DR: A mechanistic computational model with predictive powers for describing RSV infection kinetics in cotton rats was constructed synergistically with in vitro and in vivo measurements and determined an important role for CD8+ T cells responses in reducing RSV titers in Cotton rats.
Severe SARS-CoV-2 disease in the context of a NF-κB2 loss-of-function pathogenic variant.
Roshini S. Abraham,Joanna M. Marshall,Hye Sun Kuehn,Cesar M. Rueda,Amber Gibbs,Will Guider,Claire Stewart,Sergio D. Rosenzweig,Huanyu Wang,Sophonie Jean,Mark E. Peeples,Mark E. Peeples,Tiffany King,Tiffany King,W. Garrett Hunt,W. Garrett Hunt,Jonathan R. Honegger,Jonathan R. Honegger,Octavio Ramilo,Octavio Ramilo,Peter J. Mustillo,Peter J. Mustillo,Asuncion Mejias,Asuncion Mejias,Monica I Ardura,Monica I Ardura,Masako Shimamura,Masako Shimamura +27 more
TL;DR: The functional consequence and immunological phenotype of a novel NFKB2 LOF variant in a 17y old male patient and the clinical management of SARS-CoV-2 infection in this context are evaluated.