17 Papers
108 Citations
Tie Wu is an academic researcher from Guangdong Medical College. The author has contributed to research in topics: Osteoporosis & Cancellous bone. The author has an hindex of 13, co-authored 17 publications.
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Papers
Salvianolic acid B promotes osteogenesis of human mesenchymal stem cells through activating ERK signaling pathway
TL;DR: The results showed Salvianolic acid B (Sal B) had no obvious toxic effects on hMSCs, whereas Sal B supplementation (5μM) increased the alkaline phosphatase activity, osteopontin, Runx2 and osterix expression in h MSCs, indicating that Sal B promoted osteogenesis of hMSCS through activating ERK signaling pathway.
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PLGA/β-TCP composite scaffold incorporating salvianolic acid B promotes bone fusion by angiogenesis and osteogenesis in a rat spinal fusion model.
Sien Lin,Liao Cui,Guanghua Chen,Jianping Huang,Yanhua Yang,Kaijie Zou,Yuxiao Lai,Xinluan Wang,Liyi Zou,Tie Wu,Jack C. Y. Cheng,Gang Li,Bo Wei,Wayne Yuk-Wai Lee +13 more
TL;DR: It is suggested that SB-incorporated PLGA/β-TCP composite scaffold could enhance bony fusion through the promotion of osteogenesis and angiogenesis.
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Tanshinol Attenuates the Deleterious Effects of Oxidative Stress on Osteoblastic Differentiation via Wnt/FoxO3a Signaling
TL;DR: The results illustrate that Tanshinol attenuates oxidative stress via down-regulation of FoxO3a signaling, and rescues the decrease of osteoblastic differentiation through upregulation of Wnt signal under oxidative stress.
Taurine promotes human mesenchymal stem cells to differentiate into osteoblast through the ERK pathway
TL;DR: This study reveals that taurine promotes the osteogenesis of hMSCs by activating the ERK pathway.
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Decursin Isolated from Angelica gigas Nakai Rescues PC12 Cells from Amyloid β-Protein-Induced Neurotoxicity through Nrf2-Mediated Upregulation of Heme Oxygenase-1: Potential Roles of MAPK.
TL;DR: Findings suggest D augments cellular antioxidant defense capacity through both intrinsic free radical scavenging activity and activation of MAPK signal pathways that leads to Nrf2 activation, and subsequently HO-1 induction, thereby protecting the PC12 cells from Aβ 25‒35-induced oxidative cytotoxicity.