Tianyi Chen
Duke University
13 Papers
Tianyi Chen is an academic researcher from Duke University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 6 publications.
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Papers
Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis
Jeongeun Hyun,Jeongeun Hyun,Zhaoli Sun,Ali Ahmadi,Sushant Bangru,Ullas V. Chembazhi,Kuo Du,Tianyi Chen,Hidekazu Tsukamoto,Ivan Rusyn,Auinash Kalsotra,Anna Mae Diehl +11 more
TL;DR: A novel mechanism that explains why liver failure develops in patients with the clinical syndrome of SAH is revealed, suggesting that recovery from SAH might be improved by limiting adult-to-fetal reprogramming in hepatocytes.
Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration.
TL;DR: Using partial hepatectomy in mice to model liver regeneration, single-cell RNA- and ATAC-Seq was integrated to map state transitions in approximately 13,000 hepatocytes at single- cell resolution as livers regenerated, and key findings were validated with IHC.
Chromatin remodeling in peripheral blood cells reflects COVID-19 symptom severity
Nicholas S. Giroux,Shengli Ding,Micah T. McClain,Thomas W. Burke,Elizabeth Petzold,Hong A. Chung,Grecia rivera Palomino,Ergang Wang,Rui Xi,Shree Bose,Tomer Rotstein,Bradly P. Nicholson,Tianyi Chen,Ricardo Henao,Gregory D. Sempowski,Thomas N. Denny,Emily R Ko,Geoffrey S. Ginsburg,Bryan Kraft,Ephraim L. Tsalik,Christopher W. Woods,Christopher W. Woods,Christopher W. Woods,Xiling Shen +23 more
TL;DR: It is indicated that pre-seroconversion chromatin remodeling in certain innate immune populations is associated with divergence in symptom severity, and the identified transcription factors, regulatory elements, and downstream pathways provide potential prognostic markers for COVID-19 subjects.
Author Correction: Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion
N Giroux,Sheng Ding,Micah T. McClain,Thomas W. Burke,Elizabeth Petzold,Hong A. Chung,Grecia O. Rivera,Ergang Wang,Rui Xi,Shree Bose,Tomer Rotstein,Bradly P. Nicholson,Tianyi Chen,R María Angélica Henao,Gregory D. Sempowski,Thomas N. Denny,Maria Iglesias De Ussel,Lisa L. Satterwhite,Emily R Ko,Geoffrey S. Ginsburg,Bryan Kraft,Ephraim L. Tsalik,Xiling Shen,Christopher W. Woods +23 more
A beautiful day in the neighborhood: Application of single cell transcriptomics to unravel liver cell heterogeneity in diseased human livers.
Tianyi Chen,Anna Mae Diehl +1 more
TL;DR: Kim et al. as mentioned in this paper used computational methodology and advances in next generation sequencing of RNA isolates from individual cells and whole livers to characterize and compare differences in liver cell communities across a spectrum of liver diseases.