6 Papers
Tian Zhang is an academic researcher from Shandong University of Traditional Chinese Medicine. The author has contributed to research in topics: Oxidative stress & Mitochondrion. The author has an hindex of 3, co-authored 6 publications.
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Papers
Quercetin Improves Cardiomyocyte Vulnerability to Hypoxia by Regulating SIRT1/TMBIM6-Related Mitophagy and Endoplasmic Reticulum Stress.
Xing Chang,Tian Zhang,Qingyan Meng,ShiyuanWang,Peizheng Yan,Xue Wang,Duosheng Luo,Xiu-Teng Zhou,Xiu-Teng Zhou,Ruifeng Ji +9 more
TL;DR: In this paper, the authors examined the effect of quercetin on human cardiomyocytes subjected to hypoxia-induced oxidative stress damage and its underlying mechanism and found that quercETin induced reactive oxygen species overproduction and endoplasmic reticulum stress, as well as inhibited the function of the mitochondria and mitophagy, eventually leading to apoptosis.
Natural Drugs as a Treatment Strategy for Cardiovascular Disease through the Regulation of Oxidative Stress.
TL;DR: Advances in the use of active CHM components that modulate oxidative stress are reviewed, suggesting potential drugs for the treatment of various CVDs.
SIRT5-Related Desuccinylation Modification Contributes to Quercetin-Induced Protection against Heart Failure and High-Glucose-Prompted Cardiomyocytes Injured through Regulation of Mitochondrial Quality Surveillance.
Xing Chang,Tian Zhang,Junyan Wang,Yan Liu,Peizheng Yan,Qingyan Meng,Yongtian Yin,Shiyuan Wang +7 more
TL;DR: In this article, the authors investigated whether SIRT5 and IDH2-related desuccinylation is involved in the underlying mechanism of myocardial fibrosis in heart failure while exploring related therapeutic drugs for mitochondrial quality surveillance.
Puerarin Attenuates LPS-Induced Inflammatory Responses and Oxidative Stress Injury in Human Umbilical Vein Endothelial Cells through Mitochondrial Quality Control.
Xing Chang,Tian Zhang,Dong Liu,Qingyan Meng,Peizheng Yan,Duosheng Luo,Xue Wang,XiuTeng Zhou,XiuTeng Zhou +8 more
TL;DR: In this paper, the main active component isolated from the rhizome of Pueraria lobata (Pue), an isoflavone compound with potent antioxidant properties, was found to partially regulate mitochondrial function in human umbilical vein endothelial cells and reduce or inhibit lipopolysaccharide-induced inflammatory reactions and oxidative stress injury.
Regulation of Mitochondrial Quality Control by Natural Drugs in the Treatment of Cardiovascular Diseases: Potential and Advantages.
Xing Chang,Wenjin Zhang,Zhenyu Zhao,Chunxia Ma,Tian Zhang,Qingyan Meng,Peizheng Yan,Lei Zhang,Yuping Zhao +8 more
TL;DR: In this paper, a review of the regulatory effects of natural plants, drugs, and active ingredients on mitochondria quality control (MQC) in the context of CVDs has been presented.