Tian-Xiang Xiang
University of Kentucky
30 Papers
300 Citations
Tian-Xiang Xiang is an academic researcher from University of Kentucky. The author has contributed to research in topics: Glass transition & Chemistry. The author has an hindex of 19, co-authored 30 publications.
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Papers
Liposomal drug transport: a molecular perspective from molecular dynamics simulations in lipid bilayers.
TL;DR: Significant progress in molecular dynamics simulation methodologies applied to lipid bilayer membranes is making it possible to move beyond characterization of the membranes themselves to explore various thermodynamic and kinetic processes governing membrane binding and transport, which is likely to be directly applicable to the design and optimization of liposomal delivery systems.
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Hydrogen Bonding Interactions in Amorphous Indomethacin and Its Amorphous Solid Dispersions with Poly(vinylpyrrolidone) and Poly(vinylpyrrolidone-co-vinyl acetate) Studied Using (13)C Solid-State NMR.
TL;DR: The present work highlights the potential of (13)C solid-state NMR to detect and quantify various hydrogen bonded species in amorphous solid dispersions as well as to serve as an experimental validation of MD simulations.
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Molecular dynamics simulation of amorphous indomethacin–poly(vinylpyrrolidone) glasses: Solubility and hydrogen bonding interactions
TL;DR: Investigation of amorphous systems of indomethacin in poly(vinylpyrrolidone) (PVP) and their molecular interactions by means of molecular dynamics simulations finds that molecular mobility as characterized by atomic fluctuations was substantially reduced below the T(g) with IMC-PVP systems exhibiting lower mobilities than that found inAmorphous IMC, consistent with the antiplasticizing effect of PVP.
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Molecular dynamics simulation of amorphous indomethacin.
TL;DR: A novel analytical method is proposed to deal with the non-Einsteinian behavior, in which the temporal evolution of the apparent diffusivity D(t) is described by a relaxation model such as the KWW function and extrapolated to infinite time.
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Enhanced active liposomal loading of a poorly soluble ionizable drug using supersaturated drug solutions.
TL;DR: A novel method was developed for creating and maintaining supersaturation of a poorly soluble camptothecin analogue, AR-67, using a low concentration of a cyclodextrin to inhibit crystallization over a 48 h period, and may have general application in overcoming the formulation challenges associated with the liposomal delivery of poorly soluble, ionizable anticancer agents.
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