Thor Arnason
deCODE genetics
4 Papers
227 Citations
Thor Arnason is an academic researcher from deCODE genetics. The author has contributed to research in topics: Genetic linkage & Candidate gene. The author has an hindex of 4, co-authored 4 publications.
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Papers
Profiling of genes expressed in peripheral blood mononuclear cells predicts glucocorticoid sensitivity in asthma patients
Hakon Hakonarson,Unnur S. Bjornsdottir,Eva Halapi,Jonathan P. Bradfield,Florian Zink,Magali Mouy,Hildur Helgadóttir,Asta Solilja Gudmundsdottir,Hjalti Andrason,Asdis E. Adalsteinsdottir,Kristleifur Kristjansson,Illugi Birkisson,Thor Arnason,Margret B. Andresdottir,David Gislason,Thorarinn Gislason,Jeffrey R. Gulcher,Kari Stefansson +17 more
TL;DR: It is concluded that gene expression profiles in PBMC that predict clinical response to inhaled GC therapy with meaningful accuracy are uncovered and support the development of a diagnostic test to guide GC therapy in asthma patients.
163
A Major Susceptibility Gene for Asthma Maps to Chromosome 14q24
Hakon Hakonarson,Unnur S. Bjornsdottir,Eva Halapi,Snæbjörn Pálsson,Elva Adalsteinsdottir,David Gislason,Gudmundur Finnbogason,Thorarinn Gislason,Kristleifur Kristjansson,Thor Arnason,Illugi Birkisson,Michael L. Frigge,Augustine Kong,Jeffrey R. Gulcher,Kari Stefansson +14 more
TL;DR: Results provide evidence of a novel susceptibility gene for asthma on chromosome 14q24, identified by cross-matching a list of patients with asthma with a genealogy database of the entire Icelandic nation and naming it "asthma locus one" (AS1).
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Allelic frequencies and patterns of single-nucleotide polymorphisms in candidate genes for asthma and atopy in Iceland.
Hakon Hakonarson,Unnur S. Bjornsdottir,Elinborg Ostermann,Thor Arnason,Asdis E. Adalsteinsdottir,Eva Halapi,Dana Shkolny,Kristleifur Kristjansson,Sigurbjorg A. Gudnadottir,Michael L. Frigge,David Gislason,Thorarinn Gislason,Augustine Kong,Jeffrey R. Gulcher,Kari Stefansson +14 more
TL;DR: It is concluded that this study has failed to produce evidence in support of the notion that variations within these 24 candidate atopy and asthma genes significantly influence the expression of the atopic asthmatic phenotype or contribute to the susceptibility of atopic asthma.
92
Genetic approaches to assessing evidence for a T helper type 1 cytokine defect in adult asthma.
Illugi Birkisson,Eva Halapi,Unnur S. Bjornsdottir,Dana Shkolny,Elva Adalsteinsdottir,Thor Arnason,David Gislason,Thorarinn Gislason,Jeffrey R. Gulcher,Kari Stefansson,Hakon Hakonarson +10 more
TL;DR: In this paper, single-nucleotide polymorphisms exist in the promoter region of the two interleukin (IL)-12 subunit genes in patients with asthma, and the results demonstrate no evidence of linkage to microsatellite markers in close association with genes within the Th1 pathway.
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