Thomas Young
Yale University
10 Papers
14 Citations
Thomas Young is an academic researcher from Yale University. The author has contributed to research in topics: DNA repair & Radial distribution function. The author has an hindex of 6, co-authored 10 publications. Previous affiliations of Thomas Young include Stanford University.
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Papers
Assembly of the Arp5 (Actin-related Protein) Subunit Involved in Distinct INO80 Chromatin Remodeling Activities.
TL;DR: It is demonstrated that the previously uncharacterized Ies2 subunit is required for Arp5-Ies6 association with the catalytic components of the INO80 complex, which defines the requirements of Arp 5-Iees6 assembly, which is needed to couple ATP hydrolysis to productive nucleosome movement.
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Quantitative Insights into Age-Associated DNA-Repair Inefficiency in Single Cells.
TL;DR: The impact of cellular aging on the efficiency of single-strand annealing (SSA), a DSB repair mechanism, is characterized and the involvement of cell-cycle regulation in age-associated repair inefficiency is confirmed.
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Quantitative insights into age-associated DNA-repair inefficiency in single cells
Thomas Young,Ping Liu,Murat Acar +2 more
TL;DR: The impact of cellular aging on the efficiency of single-strand annealing (SSA), a repair mechanism for DSBs occurring between direct repeats, is characterized and increased G1-phase duration in old cells is identified as a factor responsible for decreased SSA repair efficiency.
13
Characterization of the impact of GMP/GDP synthesis inhibition on replicative lifespan extension in yeast.
TL;DR: It is demonstrated that the lifespan extension is facilitated by slowing, rather than reversing, the aging process in cells, and the existence of clinically-approved GMP pathway inhibitors elicits the potential of a new class of therapeutics for aging-related disorders.
5
Inhibition of GMP synthesis extends yeast replicative lifespan
Ethan A. Sarnoski,Ping Liu,Guste Urbonaite,Tolga T. Olmez,Thomas Young,Ruijie Song,Murat Acar +6 more
TL;DR: It is demonstrated that the lifespan extension by GMP insufficiency is facilitated by slowing, rather than reversing, the aging process in cells, which rule out the combined effect of global transcription and translation on cellular lifespan.