Thomas Wolf
University Hospital Heidelberg
18 Papers
45 Citations
Thomas Wolf is an academic researcher from University Hospital Heidelberg. The author has contributed to research in topics: Cancer & Head and neck squamous-cell carcinoma. The author has an hindex of 13, co-authored 18 publications. Previous affiliations of Thomas Wolf include Heidelberg University & Hannover Medical School.
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Papers
The landscape of metastatic progression patterns across major human cancers.
Jan Budczies,Moritz von Winterfeld,Frederick Klauschen,Michael Bockmayr,Jochen K. Lennerz,Carsten Denkert,Thomas Wolf,Arne Warth,Manfred Dietel,Ioannis Anagnostopoulos,Wilko Weichert,Daniel Wittschieber,Albrecht Stenzinger +12 more
TL;DR: Analysis of patterns of metastatic progression across 16 major cancer types in a cohort of 1008 patients with metastatic cancer autopsied between 2000 and 2013 showed that metastatic patterns help to predict unknown primary sites.
Induction of Chromosome Instability by Activation of Yes-Associated Protein and Forkhead Box M1 in Liver Cancer
S Weiler,Federico Pinna,Thomas Wolf,Teresa Lutz,Aman Geldiyev,Carsten Sticht,M Knaub,Stefan Thomann,Michaela Bissinger,S Wan,S Rössler,D Becker,Norbert Gretz,Hauke Lang,Frank Bergmann,Vladimir Ustiyan,Tatiana V. Kalin,Stephan Singer,Ju Seog Lee,Jens U. Marquardt,Peter Schirmacher,Vladimir V. Kalinichenko,Kai Breuhahn +22 more
TL;DR: By analyzing cell lines, genetically modified mice, and HCC tissues, it is found that YAP cooperates with FOXM1 to contribute to chromosome instability and agents that disrupt this pathway might be developed as treatments for liver cancer.
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DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer
Soulafa Mamlouk,Soulafa Mamlouk,Liam Harold Childs,Daniela Aust,Daniel Heim,Friederike Melching,Cristiano Oliveira,Thomas Wolf,Pawel Durek,Dirk Schumacher,Dirk Schumacher,Hendrik Bläker,Moritz von Winterfeld,Bastian Gastl,Kerstin Möhr,Andrea Menne,Andrea Menne,Silke Zeugner,Torben Redmer,Torben Redmer,Dido Lenze,Sascha Tierling,Markus Möbs,Wilko Weichert,Gunnar Folprecht,Eric Blanc,Dieter Beule,Reinhold Schäfer,Reinhold Schäfer,Markus Morkel,Frederick Klauschen,Ulf Leser,Christine Sers +32 more
TL;DR: Analysis of DNA sequence and DNA copy-number heterogeneity in colorectal cancer by targeted high-depth sequencing of 100 most frequently altered genes identifies evenly distributed coding mutations in APC and TP53 in all tumour areas, yet highly variable gene copy numbers in numerous genes.
Targeted ultra-deep sequencing reveals recurrent and mutually exclusive mutations of cancer genes in blastic plasmacytoid dendritic cell neoplasm
Albrecht Stenzinger,Volker Endris,Nicole Pfarr,Mindaugas Andrulis,Korinna Jöhrens,Frederick Klauschen,Udo Siebolts,Thomas Wolf,Philipp-Sebastian Koch,Miriam Schulz,Wolfgang Hartschuh,Sergij Goerdt,Jochen K. Lennerz,Claudia Wickenhauser,Wolfram Klapper,Ioannis Anagnostopoulos,Wilko Weichert +16 more
TL;DR: NRAS, KRAS and ATM mutations were found to be mutually exclusive and recurrent mutations in NRAS, IDH2, APC and ATM were observed, which may point to different subgroups of BPDCN whose biological significance remains to be explored.
Mutations in POLE and survival of colorectal cancer patients--link to disease stage and treatment.
Albrecht Stenzinger,Nicole Pfarr,Volker Endris,Roland Penzel,Lina Jansen,Thomas Wolf,Esther Herpel,Arne Warth,Frederick Klauschen,Matthias Kloor,Wilfried Roth,Hendrik Bläker,Jenny Chang-Claude,Hermann Brenner,Michael Hoffmeister,Wilko Weichert +15 more
TL;DR: POLE EDMs do not appear to define an entirely new clinically distinct disease entity in CRC but may have prognostic or predictive implications in CRC subgroups, whose significance remains to be investigated in future studies.
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