Thomas W. Barlow
University of Oxford
4 Papers
43 Citations
Thomas W. Barlow is an academic researcher from University of Oxford. The author has contributed to research in topics: Protein design & Pattern recognition (psychology). The author has an hindex of 4, co-authored 4 publications.
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Papers
Self-organizing maps and molecular similarity
TL;DR: Self-organizing maps generated by Kohonen neural networks provide a method for transforming multidimensional problems into lower dimensional problems and are extended to rank histamine H2 agonists in order of biological activity.
29
A novel representation of protein structure
TL;DR: Using a nonlinear mapping technique, it is demonstrated that proteins folded in two dimensions display the same overall structural features as their three-dimensional counterparts.
12
A one-dimensional representation of protein structure.
TL;DR: A one-dimensional representation of protein structure in terms of angles between C alpha-C alpha links in a two- dimensional representation describes tertiary structure to an accuracy of approximately 3 A.
5
Reduced Dimensional Representations of Molecular Structure
TL;DR: The technique is shown to be trivial so long as the molecular structure is not essentially spherical and an objective test as to whether this is true is introduced, together with extensions for coping with such cases.