Thomas Stoeger

TL;DR: In this article, the authors performed an integrated analysis of single-cell RNA-Seq data that revealed homogenous age-related changes in the alveolar macrophage transcriptome in humans and mice.

TL;DR: A cell-intrinsic molecular mechanism that allows multicellular patterning without requiring specific communication between cells is revealed and suggests a fundamental role for a tunable membrane lipid composition in collective cell behaviour.

TL;DR: In this article , the authors show that transcript length alone explains most transcriptional changes observed with aging in mice and humans, and they present three lines of evidence supporting the biological importance of the uncovered transcriptome imbalance.

TL;DR: The setup of the experimental pipeline for image-based transcriptomics is discussed, and the algorithms that were developed to extract, at high-throughput, robust multivariate feature sets of transcript molecule abundance, localization and patterning in tens of thousands of single cells across the transcriptome are described.