Thomas Schröter
Scripps Research Institute
18 Papers
99 Citations
Thomas Schröter is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Rho-associated protein kinase & Kinase. The author has an hindex of 15, co-authored 18 publications. Previous affiliations of Thomas Schröter include Scripps Health.
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Papers
AAK1-mediated μ2 phosphorylation is stimulated by assembled clathrin
TL;DR: It is reported that Aak1 is an atypical kinase that is rate limited by its stable association with AP2 and that clathrin stimulates μ2 phosphorylation by AAK1, and a model in which AAK 1 is specifically activated in coated pits to enhance cargo recruitment and efficient internalization is suggested.
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Chroman-3-amides as potent Rho kinase inhibitors
Yen Ting Chen,Thomas D. Bannister,Amiee Weiser,Evelyn Griffin,Li Lin,Claudia Ruiz,Michael D. Cameron,Stephan C. Schürer,Derek R. Duckett,Thomas Schröter,Philip LoGrasso,Yangbo Feng +11 more
TL;DR: Ch chroman-3-amides are reported as highly potent ROCK inhibitors with sufficient kinase selectivity, excellent cell activity, good microsomal stability, and desirable pharmacokinetic properties for study as potential therapeutic agents.
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Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors.
Yan Yin,Li Lin,Claudia Ruiz,Michael D. Cameron,Jennifer Pocas,Wayne Grant,Thomas Schröter,Weimin Chen,Derek R. Duckett,Stephan C. Schürer,Philip LoGrasso,Yangbo Feng +11 more
TL;DR: A series of benzothiazole derivatives as ROCK inhibitors have been discovered with good biochemical and cellular potency, and sufficient kinase selectivity.
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Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I).
Sarwat Chowdhury,E. Hampton Sessions,Jennifer Pocas,Wayne Grant,Thomas Schröter,Li Lin,Claudia Ruiz,Michael D. Cameron,Stephan C. Schürer,Philip LoGrasso,Thomas D. Bannister,Yangbo Feng +11 more
TL;DR: In this paper, the optimization and biological evaluation of potent novel Rho kinase (ROCK) inhibitors based on substituted indole and 7-azaindole core scaffolds was performed.
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Discovery of Potent and Selective Urea-Based ROCK Inhibitors and Their Effects on Intraocular Pressure in Rats
Yan Yin,Michael D. Cameron,Li Lin,Susan Khan,Thomas Schröter,Wayne Grant,Jennifer Pocas,Yen Ting Chen,Stephan C. Schürer,Alok Pachori,Philip LoGrasso,Yangbo Feng +11 more
TL;DR: A series of urea-based Rho kinase (ROCK) inhibitors were designed and evaluated and had excellent enzyme and cellular potency, high kinase selectivity, high aqueous solubility, good porcine corneal penetration, and appropriate DMPK profiles for topical applications as antiglaucoma therapeutics.
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