Thomas Renne
Université de Montréal
3 Papers
8 Citations
Thomas Renne is an academic researcher from Université de Montréal. The author has contributed to research in topics: Copy-number variation & Haploinsufficiency. The author has an hindex of 2, co-authored 3 publications. Previous affiliations of Thomas Renne include Centre Hospitalier Universitaire Sainte-Justine & University of Rouen.
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Papers
Genome-wide analysis of gene dosage in 24,092 individuals estimates that 10,000 genes modulate cognitive ability.
Guillaume Huguet,Guillaume Huguet,Catherine Schramm,Catherine Schramm,Catherine Schramm,Elise Douard,Elise Douard,Petra Tamer,Petra Tamer,Antoine Main,Antoine Main,Pauline Monin,Pauline Monin,Jade England,Jade England,Khadije Jizi,Khadije Jizi,Thomas Renne,Thomas Renne,Myriam Poirier,Myriam Poirier,Sabrina Nowak,Sabrina Nowak,Charles-Olivier Martin,Charles-Olivier Martin,Nadine Younis,Nadine Younis,Inga Sophia Knoth,Inga Sophia Knoth,Martineau Jean-Louis,Martineau Jean-Louis,Zohra Saci,Zohra Saci,Maude Auger,Maude Auger,Frédérique Tihy,Frédérique Tihy,Géraldine Mathonnet,Géraldine Mathonnet,Catalina Maftei,Catalina Maftei,David J. Porteous,David J. Porteous,Gail Davies,Paul Redmond,Sarah E. Harris,W. David Hill,Emmanuelle Lemyre,Emmanuelle Lemyre,Gunter Schumann,Thomas Bourgeron,Thomas Bourgeron,Thomas Bourgeron,Zdenka Pausova,Tomáš Paus,Sherif Karama,Sarah Lippé,Sarah Lippé,Ian J. Deary,Laura Almasy,Aurélie Labbe,David C. Glahn,David C. Glahn,Celia M. T. Greenwood,Celia M. T. Greenwood,Sébastien Jacquemont,Sébastien Jacquemont +66 more
TL;DR: In this paper, the effect of deletions and duplications on cognitive ability can be statistically predicted using measures of intolerance to haploinsufficiency, and the effect sizes of duplications remain unknown.
Estimating the effect-size of gene dosage on cognitive ability across the coding genome
Guillaume Huguet,Catherine Schramm,Elise Douard,Petra Tamer,Antoine Main,Pauline Monin,Jade England,Khadije Jizi,Thomas Renne,Myriam Poirier,Sabrina Nowak,Charles-Olivier Martin,Nadine Younis,Inga Sophia Knoth,Martineau Jean Louis,Zohra Saci,Maude Auger,Frédérique Tihy,Géraldine Mathonnet,Catalina Maftei,David J. Porteous,Gail Davies,Paul Redmond,Sarah E. Harris,Emmanuelle Lemyre,Gunter Schumann,Thomas Bourgeron,Zdenka Pausova,Tomáš Paus,Sherif Karama,Sarah Lippé,Ian J. Deary,Laura Almasy,Aurélie Labbe,David C. Glahn,Celia M. T. Greenwood,Sébastien Jacquemont +36 more
TL;DR: This first outline for the effect sizes of all coding genes on intelligence suggests that around 10,000 genes affect this trait.
Genome wide analysis of gene dosage in 24,092 individuals shows that 10,000 genes modulate cognitive ability
Guillaume Huguet,Catherine Schramm,Elise Douard,Petra Tamer,Antoine Main,Pauline Monin,Jade England,Khadije Jizi,Thomas Renne,Myriam Poirier,Sabrina Nowak,Charles-Olivier Martin,Nadine Younis,Inga Sophia Knoth,Martineau Jean Louis,Zohra Saci,Maude Auger,Frédérique Tihy,Géraldine Mathonnet,Catalina Maftei,David J. Porteous,Gail Davies,Paul Redmond,Sarah E. Harris,Emmanuelle Lemyre,Gunter Schumann,Thomas Bourgeron,Zdenka Pausova,Tomáš Paus,Sherif Karama,Sarah Lippé,Ian J. Deary,Laura Almasy,Aurélie Labbe,David C. Glahn,Celia M. T. Greenwood,Sébastien Jacquemont +36 more
TL;DR: Genomic Copy Number Variants are routinely identified and reported back to patients with neuropsychiatric disorders, but their quantitative effects on essential traits such as cognitive ability are poorly documented, and pervasive effects on cognition may be related to emergent properties of the genome not restricted to a limited number of biological pathways.
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