Thomas R. Cox
14 Papers
2 Citations
Thomas R. Cox is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 1 publications.
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Papers
Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis
Michael Papanicolaou,Amelia L. Parker,Michelle Yam,Elysse C. Filipe,Sunny Z. Wu,Jessica L. Chitty,Kaitlin Wyllie,Emmi Tran,Ellie Mok,A. Nadalini,Joanna N. Skhinas,Morghan C. Lucas,David Herrmann,Max Nobis,Brooke A. Pereira,Andrew M. K. Law,Lesley Castillo,Kendelle J. Murphy,Anaiis Zaratzian,Jordan F. Hastings,David R. Croucher,Elgene Lim,Brian G. Oliver,Fátima Valdés Mora,Benjamin L. Parker,David Gallego-Ortega,Alexander Swarbrick,Sandra A O'Toole,Paul Timpson,Thomas R. Cox +29 more
TL;DR: In this article , the authors used temporal proteomic profiling of decellularized breast cancer to identify four key matrisomal clusters and pinpoint collagen type XII as a critical component that regulates collagen type I organisation.
Bovine and human endometrium-derived hydrogels support organoid culture from healthy and cancerous tissues
M Fairuz B Jamaluddin,Arnab Ghosh,Aviraj Ingle,Riazuddin Mohammed,Ayesha Ali,M. Bahrami,Gerard E. Kaiko,Zamira Gibb,Elysse C. Filipe,Thomas R. Cox,Angela Boulton,Rachel O'Sullivan,Yvette Ius,Ajay S. Karakoti,Ajayan Vinu,Pravin Nahar,Kenneth Jaaback,Vipul Bansal,Pradeep S. Tanwar +18 more
TL;DR: Endometrial hydrogels overcome a major limitation of organoid technology and greatly expand the applicability of organoids to understand endometrial biology and associated pathologies.
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A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer
Jessica L. Chitty,Michelle Yam,Lara Perryman,Amelia L. Parker,Joanna N. Skhinas,Yordanos F I Setargew,Ellie Mok,Emmi Tran,Rhiannon Grant,Sharissa L. Latham,Brooke A. Pereira,Shona Ritchie,Kendelle J. Murphy,Michael Trpceski,Alison D. Findlay,Pauline Melenec,Elysse C. Filipe,A. Nadalini,Sipiththa Velayuthar,Gretel Major,Kaitlin Wyllie,Michael Papanicolaou,Shivanjali Ratnaseelan,Phoebe A. Phillips,George Sharbeen,Janet Youkhana,Alice G. Russo,Antonia Blackwell,Jordan F. Hastings,Morghan C. Lucas,Cecilia R. Chambers,Daniel A Reed,Janett Stoehr,Claire Vennin,Ruth Pidsley,Anaiis Zaratzian,Andrew M. Da Silva,Michael Tayao,Bret Charlton,David Herrmann,Max Nobis,P. J. Clark,Andrew V. Biankin,Amber L. Johns,David R. Croucher,Adnan Nagrial,Anthony J. Gill,Sean M. Grimmond,Lorraine A. Chantrill,Angela Chou,Tanya Dwarte,Xanthe L Metcalf,G. Jeong,Lara Kenyon,Nicola Waddell,John V. Pearson,Ann-Marie Patch,Katia Nones,Felicity Newell,Pamela Mukhopadhyay,Venkateswar Addala,Stephen H. Kazakoff,Oliver Holmes,Conrad Leonard,Scott Wood,Oliver Hofmann,Jaswinder S. Samra,Nick Pavlakis,Jennifer Arena,H. High,Ray Asghari,Neil Merrett,Amitabha Das,P. Cosman,Kasim Ismail,A. Stoita,David B. Williams,Allan Spigellman,Duncan McLeo,Judy Kirk,James G. Kench,Peter Grimison,Charbel Sandroussi,Annabel Goodwin,R. S. Mead,Katherine L. Tucker,Lesley Andrews,M. Texler,Cindy Forrest,M. Ballal,D. Fletcher,M. V. Beilin,Kynan Feeney,K. Epari,Sanjay Mukhedkar,Nikolajs Zeps,Nan Q. Nguyen,Andrew Ruszkiewicz,C. Worthley,John Chen,Mark Brooke-Smith,V. Papangelis,Andrew D. Clouston,Andrew Barbour,T. J. O'Rourke,J. W. Fawcett,Kellee Slater,M. Hatzifotis,Peter Franklin Myra Hodgkinson,Mehrdad Nikfarjam,James R. Eshleman,Ralph H. Hruban,Christopher L. Wolfgang,Aldo Scarpa,Rita T. Lawlor,Vincenzo Corbo,Claudio Bassi,Nigel B. Jamieson,David K. Chang,Stephan Dreyer,Lea Abdulkhalek,T. Schmitz,Victoria Lee,Kym Pham Stewart,M. Arshi,Angela Steinmann,Marina Pajic,Paul Timpson,Wolfgang Jarolimek,Thomas R. Cox +129 more
TL;DR: PXS-5505, a first-in-class selective pan-lysyl oxidase inhibitor, is developed and validated and it reduces chemotherapy-induced desmoplasia and stiffness, thereby improving chemotherapy response and survival in pancreatic cancer models.
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miRNAs in pancreatic cancer progression and metastasis.
Ellie T Y Mok,Jessica L. Chitty,Thomas R. Cox +2 more
TL;DR: The role of miRNAs in PDAC, the downstream signalling pathways that they play a role in, how these are being used and studied as therapeutic targets as well as prognostic/diagnostic tools to improve the clinical outcome of PDAC are summarized.
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Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma
Jordan F. Hastings,Sharissa L. Latham,Alvin Kamili,Madeleine S. Wheatley,Jeremy Z. R. Han,Marie Wong-Erasmus,Monica Phimmachanh,Max Nobis,Chiara Pantarelli,Antonia L Cadell,Yolande E. I. O’Donnell,King Ho Leong,Sophie Lynn,Fan-Suo Geng,Lujing Cui,Sabrina Yan,Joanna Achinger-Kawecka,Clare Stirzaker,Murray D. Norris,Michelle Haber,Toby Trahair,Franki Speleman,Katleen De Preter,Mark J. Cowley,Ozren Bogdanovic,Paul Timpson,Thomas R. Cox,Walter Kolch,Jamie I. Fletcher,Dirk Fey,David R. Croucher +30 more
TL;DR: In this article , the influence of gene expression noise is integrated across multiple components of an apoptotic signaling network, and the memory of this initially random state is retained following chemotherapy treatment across a series of in vitro, in vivo, and patient models.
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