Thomas Q. de Aguiar Vallim
University of California, Los Angeles
65 Papers
112 Citations
Thomas Q. de Aguiar Vallim is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Lipid metabolism & Biology. The author has an hindex of 23, co-authored 46 publications. Previous affiliations of Thomas Q. de Aguiar Vallim include University of Nottingham.
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Papers
Pleiotropic Roles of Bile Acids in Metabolism
TL;DR: This review covers the roles of specific bile acids, synthetic agonists, and their cognate receptors in controlling these diverse functions, as well as their current use in treating human diseases.
1K
Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation
Brian J. Bennett,Thomas Q. de Aguiar Vallim,Zeneng Wang,Diana M. Shih,Yonghong Meng,Jill C. Gregory,Hooman Allayee,Richard G. Lee,Mark J. Graham,Rosanne M. Crooke,Peter A. Edwards,Stanley L. Hazen,Aldons J. Lusis +12 more
TL;DR: It is demonstrated that two flavin mono-oxygenase family members, FMO1 and FMO3, oxidize trimethylamine (TMA), derived from gut flora metabolism of choline, to TMAO, and it is shown that F MO3 exhibits 10-fold higher specific activity than F MO1.
948
The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance.
Manya Warrier,Diana M. Shih,Amy C. Burrows,Daniel Ferguson,Anthony D. Gromovsky,Amanda L. Brown,Stephanie M. Marshall,Allison L. McDaniel,Rebecca C. Schugar,Zeneng Wang,Jessica Sacks,Xin Rong,Thomas Q. de Aguiar Vallim,Jeff W. Chou,Pavlina T. Ivanova,David S. Myers,H. Alex Brown,Richard G. Lee,Rosanne M. Crooke,Mark J. Graham,Xiuli Liu,Paolo Parini,Peter Tontonoz,Peter Tontonoz,Aldon J. Lusis,Stanley L. Hazen,Ryan E. Temel,J. Mark Brown +27 more
TL;DR: In this article, the authors performed transcriptional profiling in mouse models of altered reverse cholesterol transport (RCT) and serendipitously identified the TMAO-generating enzyme flavin monooxygenase 3 as a powerful modifier of cholesterol metabolism and RCT.
371
Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis
Diana M. Shih,Zeneng Wang,Richard G. Lee,Yonghong Meng,Nam Che,Sarada Charugundla,Hannah Qi,Judy Wu,Calvin Pan,J. Mark Brown,Thomas Q. de Aguiar Vallim,Brian J. Bennett,Mark J. Graham,Stanley L. Hazen,Aldons J. Lusis +14 more
TL;DR: The results indicate a major role for FMO3 in modulating glucose and lipid homeostasis in vivo, and they suggest that pharmacologic inhibition of F MO3 to reduce TMAO levels would be confounded by metabolic interactions.
301
Role of ABC transporters in lipid transport and human disease.
TL;DR: This review highlights the role of ABC transporters in lipid transport and movement, in addition to discussing their roles in cellular homeostasis and inherited disorders.
279