Thomas Nicholson
University of Birmingham
22 Papers
20 Citations
Thomas Nicholson is an academic researcher from University of Birmingham. The author has contributed to research in topics: Medicine & Skeletal muscle. The author has an hindex of 6, co-authored 14 publications. Previous affiliations of Thomas Nicholson include Heart of England NHS Foundation Trust.
Chat about Author
Papers
IL-6 secretion in osteoarthritis patients is mediated by chondrocyte-synovial fibroblast cross-talk and is enhanced by obesity
Mark J. Pearson,Dietmar Herndler-Brandstetter,Mohammad Ahsan Tariq,Thomas Nicholson,Ashleigh M. Philp,Hannah L. Smith,Edward T. Davis,Simon W. Jones,Janet M. Lord +8 more
TL;DR: It is suggested that obesity enhances the cross-talk between chondrocytes and synovial fibroblasts via raised levels of the pro-inflammatory adipokine leptin, leading to greater production of IL-6 in OA patients.
The role of adipokines in skeletal muscle inflammation and insulin sensitivity
TL;DR: The mechanism of action and function of adipokines in mediating insulin sensitivity in skeletal muscle may lead to the development of novel therapeutics for patients with type 2 diabetes, but to date studies conducted in human skeletal muscle cells and tissues are limited.
circSamd4 represses myogenic transcriptional activity of PUR proteins
Poonam R. Pandey,Jen-Hao Yang,Dimitrios Tsitsipatis,Amaresh C. Panda,Ji Heon Noh,Ji Heon Noh,Kyoung Mi Kim,Kyoung Mi Kim,Rachel Munk,Thomas Nicholson,Douglas Hanniford,Diana Argibay,Xiaoling Yang,Jennifer L. Martindale,Ming-Wen Chang,Simon W. Jones,Eva Hernando,Payel Sen,Supriyo De,Kotb Abdelmohsen,Myriam Gorospe +20 more
TL;DR: RNA sequencing analysis of circRNAs differentially expressed during myogenesis revealed that circSamd4 expression increased robustly in mouse C2C12 myoblasts differentiating into myotubes, and the association of PUR proteins with circSamD4 enhances myogenesis by contributing to the derepression of MHC transcription.
Mechanical chest compression devices at in-hospital cardiac arrest: A systematic review and meta-analysis
Keith Couper,Joyce Yeung,Thomas Nicholson,Tom Quinn,Ranjit Lall,Gavin D. Perkins,Gavin D. Perkins +6 more
TL;DR: Mechanical chest compression devices may improve patient outcome, when used at in-hospital cardiac arrest, however, the quality of current evidence is very low and there is a need for randomised trials to evaluate the effect of mechanical chest compression device on survival for in- hospital cardiac arrest.
61
Obese subcutaneous adipose tissue impairs human myogenesis, particularly in old skeletal muscle, via resistin-mediated activation of NFκB.
Mary F. O’Leary,Graham R. Wallace,Edward T. Davis,David Murphy,Thomas Nicholson,Andrew J. Bennett,Kostas Tsintzas,Simon W. Jones +7 more
TL;DR: Resin derived from human obese subcutaneous adipose tissue impairs myogenesis of human skeletal muscle, particularly older muscle, and alters muscle metabolism in developing myotubes, which may have important implications for the maintenance of muscle mass in older people with chronic inflammatory conditions, or older people who are obese or overweight.