Thomas N. Snaddon
Indiana University
38 Papers
64 Citations
Thomas N. Snaddon is an academic researcher from Indiana University. The author has contributed to research in topics: Chemistry & Catalysis. The author has an hindex of 15, co-authored 31 publications. Previous affiliations of Thomas N. Snaddon include Merck & Co. & Max Planck Society.
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Papers
Uniting C1-Ammonium Enolates and Transition Metal Electrophiles via Cooperative Catalysis: The Direct Asymmetric α-Allylation of Aryl Acetic Acid Esters
TL;DR: This conceptual approach to cooperative catalysis constitutes a potentially general solution to the direct catalytic asymmetric α-functionalization of acyclic esters.
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A Regio- and Stereodivergent Synthesis of Homoallylic Amines by a One-Pot Cooperative-Catalysis-Based Allylic Alkylation/Hofmann Rearrangement Strategy.
TL;DR: A modular synthetic route to linear and branched homoallylic amines that operates via a sequential one-pot Lewis base/transition metal catalyzed allylic alkylation/Hofmann rearrangement strategy that enables all aspects of regio- and stereoselectivity to be controlled via a conserved experimental protocol is reported.
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Enantioselective α-Benzylation of Acyclic Esters Using π-Extended Electrophiles.
TL;DR: The first asymmetric cooperative Lewis base/palladium catalyzed benzylic alkylation of acyclic esters is reported, and this reaction proceeds via stereodefined C1-ammonium enolate nucleophiles.
A Synthesis-Driven Structure Revision of Berkelic Acid Methyl Ester†
Philipp Buchgraber,Thomas N. Snaddon,Cornelia Wirtz,Richard Mynott,Richard Goddard,Alois Fürstner +5 more
TL;DR: Investigations on berkelic acid methyl ester suggest that the original structure assignment needs to be revised, and preliminary activity and selectivity data are highly encouraging.
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Direct Conversion of N-Methoxy-N-methylamides (Weinreb Amides) to Ketones via a Nonclassical Wittig Reaction
John A. Murphy,Aurelien G. J. Commeureuc,Thomas N. Snaddon,Thomas M. McGuire,Tanweer A. Khan,Kevin Hisler,Mark L. Dewis,Robert W. Carling +7 more
TL;DR: N-Methoxy-N-methylamides (Weinreb amides) are converted efficiently into ketones by reaction with alkylidenetriphenylphosphoranes and in situ hydrolysis of the product.
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