Thomas M. Suchyna
University at Buffalo
42 Papers
336 Citations
Thomas M. Suchyna is an academic researcher from University at Buffalo. The author has contributed to research in topics: Mechanosensitive channels & Ion channel. The author has an hindex of 26, co-authored 42 publications. Previous affiliations of Thomas M. Suchyna include University of Bonn & State University of New York System.
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Papers
Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers.
Thomas M. Suchyna,Sonya E. Tape,Roger E. Koeppe,Olaf S. Andersen,Frederick Sachs,Philip A. Gottlieb +5 more
TL;DR: The results suggest that modulation of membrane proteins by amphipathic peptides—mechanopharmacology—involves not only the protein itself but also the surrounding lipids, and the surprising efficacy of the d form of GsMTx4 has important therapeutic implications, because d peptides are not hydrolysed by endogenous proteases and may be administered orally.
296
Biophysics and Structure of the Patch and the Gigaseal
TL;DR: High ionic strength pipette saline increased E(a) and, surprisingly, increased cytoskeletal rigidity in cell-attached patches and Voltage-dependent creep seems to arise from electroosmosis in the seal.
199
GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels.
Radhakrishnan Gnanasambandam,Chiranjib Ghatak,Anthony Yasmann,Kazuhisa Nishizawa,Frederick Sachs,Alexey S. Ladokhin,Sergei Sukharev,Thomas M. Suchyna +7 more
TL;DR: A model placing GsMTx4 at the membrane surface, where it is stabilized by the lysines, and occupying a small fraction of the surface area in unstressed membranes is suggested, supported by molecular dynamics simulations of the peptide-monolayer system under different area constraints.
190
A fluorescence energy transfer‐based mechanical stress sensor for specific proteins in situ
TL;DR: To measure mechanical stress in real time, a fluorescence resonance energy transfer (FRET) cassette was designed, denoted stFRET, which could be inserted into structural protein hosts and expressed well and distributed normally in cell lines such as 3T3, where they were stressed at the leading edge of migrating cells and relaxed at the trailing edge.
155
•Journal Article
Erratum: Gap junctions formed by connexins 26 and 32 alone and in combination are differently affected by applied voltage (Proc. Natl. Acad. Sci. USA (October 1, 1991) 88 (8410-8414))
Luis C. Barrio,Thomas M. Suchyna,Thaddeus A. Bargiello,Xian Xu Lie Xian Xu,Raymond S. Roginski,Michael V. L. Bennett,Bruce J. Nicholson +6 more
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