Thomas Lautier
University of Toulouse
27 Papers
60 Citations
Thomas Lautier is an academic researcher from University of Toulouse. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 12, co-authored 21 publications. Previous affiliations of Thomas Lautier include Institut national des sciences appliquées & Centre national de la recherche scientifique.
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Papers
Relating diffusion along the substrate tunnel and oxygen sensitivity in hydrogenase
Pierre-Pol Liebgott,Fanny Leroux,Fanny Leroux,Bénédicte Burlat,Bénédicte Burlat,Sébastien Dementin,Carole Baffert,Carole Baffert,Thomas Lautier,Thomas Lautier,Vincent Fourmond,Pierre Ceccaldi,Pierre Ceccaldi,Christine Cavazza,Isabelle Meynial-Salles,Isabelle Meynial-Salles,Philippe Soucaille,Juan C. Fontecilla-Camps,Bruno Guigliarelli,Bruno Guigliarelli,Patrick Bertrand,Patrick Bertrand,Marc Rousset,Christophe Léger +23 more
TL;DR: It is demonstrated that certain enzymes are slowly inactivated by O2 because access to the active site is slow, and the relations between diffusion, the Michaelis constant for H2 and rates of inhibition are quantitatively defined.
207
Ligand Access Channels in Cytochrome P450 Enzymes: A Review
TL;DR: This review presents different in silico tools that were developed to uncover predicted channels in P450 crystal structures and lists some of the experimental evidence that actually suggest that these predicted channels might indeed play a critical role in modulating P450 functions.
82
CO Disrupts the Reduced H-Cluster of FeFe Hydrogenase. A Combined DFT and Protein Film Voltammetry Study
Carole Baffert,Luca Bertini,Thomas Lautier,Claudio Greco,Kateryna Sybirna,Pierre Ezanno,Emilien Etienne,Philippe Soucaille,Patrick Bertrand,Hervé Bottin,Isabelle Meynial-Salles,Luca De Gioia,Christophe Léger +12 more
TL;DR: This work elucidate the mechanism by which, under certain conditions, CO binding can cause permanent damage to the H-cluster, and indicates that, like in the case of oxygen inhibition, the reaction with CO engages the entire H-Cluster, rather than only the Fe(2) subsite.
Steady-state catalytic wave-shapes for 2-electron reversible electrocatalysts and enzymes.
Vincent Fourmond,Carole Baffert,Kateryna Sybirna,Thomas Lautier,Abbas Abou Hamdan,Sébastien Dementin,Philippe Soucaille,Isabelle Meynial-Salles,Hervé Bottin,Christophe Léger +9 more
TL;DR: The interpretation of electrochemical signals obtained with adsorbed enzymes and molecular catalysts that can reversibly convert their substrate and product is discussed and there is no simple relation between the reduction potential of the active site and the catalytic bias of the enzyme.
61
Correcting for Electrocatalyst Desorption and Inactivation in Chronoamperometry Experiments
Vincent Fourmond,Thomas Lautier,Carole Baffert,Fanny Leroux,Pierre-Pol Liebgott,Sébastien Dementin,Marc Rousset,Pascal Arnoux,David Pignol,Isabelle Meynial-Salles,Phillippe Soucaille,Patrick Bertrand,Christophe Léger +12 more
TL;DR: A general and surprisingly simple method for correcting for electrocatalyst desorption and inactivation, which greatly increases the precision of chronoamperometric experiments and describes the different strategies for obtaining the control signal by analyzing various data recorded with adsorbed redox enzymes.