6 Papers
11 Citations
Thomas Ku is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Cancer & Proteome. The author has an hindex of 5, co-authored 6 publications.
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Papers
In vivo biodistribution and accumulation of 89Zr in mice.
TL;DR: (89)Zr is a bone seeker and has a strong affinity for phosphate, and the electrophoretic analyses provided detailed evidences of Zr charges either as salts or as complexes.
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Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90
Kamalika Moulick,James H. Ahn,Hongliang Zong,Anna Rodina,Leandro Cerchietti,Gomes-Dagama Erica M,Eloisi Caldas-Lopes,Kristin Beebe,Fabiana Perna,Katerina Hatzi,Ly P. Vu,Xinyang Zhao,Danuta Zatorska,Tony Taldone,Peter Smith-Jones,Mary L. Alpaugh,Steven S. Gross,Nagavarakishore Pillarsetty,Thomas Ku,Jason S. Lewis,Steven M. Larson,Ross L. Levine,Hediye Erdjument-Bromage,Monica L. Guzman,Stephen D. Nimer,Ari Melnick,Len Neckers,Gabriela Chiosis +27 more
TL;DR: This work uses PU-H71 affinity capture to design a proteomic approach that, when combined with bioinformatic pathway analysis, identifies dysregulated signaling networks and key oncoproteins in chronic myeloid leukemia and shows that this method can provide global insights into the biology of individual tumors, including primary patient specimens.
Molecular targeting of carbonic anhydrase IX in mice with hypoxic HT29 colorectal tumor xenografts.
TL;DR: For the clinical detection of hypoxia induced CAIX using cG250 antibody based agents, imaging with the intact IgG at 7 days post injection would allow for the most sensitive and accurate detection of CAIX.
Abstract 3029: Biochemical evidence towards the existence of an oncogenic Hsp90 complex
Anna Rodina,Kamalika Moulick,James H. Ahn,Hongliang Zong,Leandro Cerchietti,Erica Gomes DaGama,Eloisi Caldas-Lopes,Kristin Beebe,Fabiana Perna,Katerina Hatzi,Ly P. Vu,Xinyang Zhao,Danuta Zatorska,Tony Taldone,Peter Smith-Jones,Mary L. Alpaugh,Steven S. Gross,Nagavarakishore Pillarsetty,Thomas Ku,Jason S. Lewis,Steven M. Larson,Ross L. Levine,Hediye Erdjument-Bromage,Monica L. Guzman,Stephen D. Nimer,Ari Melnick,Len Neckers,Gabriela Chiosis +27 more
TL;DR: The data suggest that Hsp90 may execute functions necessary to maintain the malignant phenotype, and experimental evidence is presented for an additional role; that is, to facilitate scaffolding and complex formation of molecules involved in aberrantly activated signaling complexes.
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Abstract 5444: Development of a noninvasive assay to determine drug concentration in tumor during hsp90 inhibitor therapy
Tony Taldone,Nagavarakishore Pillarsetty,Mark Dunphy,John F. Gerecitano,Eloisi Caldas-Lopes,Brad Beattie,Radu I Peter,Yanlong Kang,Anna Rodina,Pengrong Yan,Erica DaGama Gomes,Alexander Bolaender,Christina Pressl,Blesida Punzalan,Anson Ku,Thomas Ku,Smit K. Shah,Mohammad Nasir Uddin,Mei H. Chen,Elmer Santos,Jacek Koziorowski,Adriana D. Corben,Shanu Modi,Komal Jhaveri,Oscar Lin,Efsevia Vakiani,Yelena Y. Janjigian,Pat Zanzonico,Clifford A. Hudis,Steven M. Larson,Jason S. Lewis,Gabriela Chiosis +31 more
TL;DR: Using PU-PET, it is demonstrated that at least one Hsp90 inhibitor exhibits tumor targeting and retention in humans, delivering and retaining therapeutic, micromolar, concentrations at safe doses.
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