Thomas Kocher
University of Basel
28 Papers
209 Citations
Thomas Kocher is an academic researcher from University of Basel. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 11, co-authored 15 publications. Previous affiliations of Thomas Kocher include Kantonsspital St. Gallen.
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Papers
•Journal Article
Identification and Intracellular Location of MAGE-3 Gene Product
Thomas Kocher,Elke Schultz-Thater,Fred Gudat,Christoph Schaefer,Giulia Casorati,Antonio Juretić,Thomas E. Willimann,Felix Harder,Michael Heberer,Giulio C. Spagnoli +9 more
TL;DR: Investigation of the human MAGE-3 gene encodes a melanoma antigenic epitope recognized by specific cytotoxic T lymphocytes and its gene product shows that it is a cytoplasmic protein, closely resembling the MAGES-1 gene product.
Prognostic relevance of MAGE-A4 tumor antigen expression in transitional cell carcinoma of the urinary bladder: a tissue microarray study.
Thomas Kocher,Thomas Kocher,Min Zheng,Martin Bolli,Ronald Simon,Thomas Forster,Elke Schultz-Thater,Eugenia Remmel,Christoph Noppen,U. Schmid,Daniel Ackermann,Michael J. Mihatsch,Thomas Gasser,Michael Heberer,Guido Sauter,Giulio C. Spagnoli +15 more
TL;DR: Evaluation of MAGE‐A4 protein expression is useful in the identification of groups of TCCs characterized by severe prognosis, thus possibly providing indications for early MAGE TAA‐targeted immunotherapy.
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Peptide‐specific ctl in tumor‐infiltrating lymphocytes from metastatic melanomas expressing mart‐1/melan‐a, gp100 and tyrosinase genes: A study in an unselected group of hla‐a2.1‐positive patients
Giulio C. Spagnoli,Christoph Schaefer,Thomas E. Willimann,Thomas Kocher,Antonio Amoroso,Antonio Juretić,Markus Zuber,Urs Lüscher,Felix Harder,Michael Heberer +9 more
TL;DR: Data indicate that CTL specific for MART‐Melan‐A27‐35, gp100280‐288 or Tyrosinase1‐9 peptides could be expanded with varying frequency from TIL derived from 4 out of 6 HLA‐A2.1+ patients whose tumors expressed the genes encoding these tumor‐associated antigens (TAA).
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Rapid Induction of Specific Cytotoxic T Lymphocytes Against Melanoma-Associated Antigens by a Recombinant Vaccinia Virus Vector Expressing Multiple Immunodominant Epitopes and Costimulatory Molecules In Vivo
Daniel Oertli,Walter R. Marti,Paul Zajac,Christoph Noppen,Thomas Kocher,Elisabetta Padovan,Michel Adamina,Reto Schumacher,Felix Harder,Michael Heberer,Giulio C. Spagnoli +10 more
TL;DR: It is concluded that active specific antitumor vaccination can raise a concurrent and specific cellular immune response against a panel of molecularly defined antigens, thereby increasing the chance of an immune hit against neoplastic cells with heterogeneous antigen expression.
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C-type lectin-like receptors in peptide-specific HLA class I-restricted cytotoxic T lymphocytes: differential expression and modulation of effector functions in clones sharing identical TCR structure and epitope specificity
Christoph Noppen,Christoph Schaefer,Paul Zajac,Alexander Schütz,Thomas Kocher,Judith Kloth,Michael Heberer,Marco Colonna,Gennaro De Libero,Giulio C. Spagnoli +9 more
TL;DR: Analysis of a panel of HLA‐A2.1‐restricted CTL clones directed against a nonapeptide derived from a melanoma‐associated antigen, dopachrome tautomerase, revealed that all clones regardless of CD94 phenotype shared Vβ22 expression, indicating that different expression of functionally active lectin‐like inhibitory receptors can be detected in CTL clone sharing identical TCR sequence and peptide specificity.
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