Thomas Kleinöder
University of Erlangen-Nuremberg
8 Papers
29 Citations
Thomas Kleinöder is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Decision support system & Reactivity (chemistry). The author has an hindex of 5, co-authored 8 publications.
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Papers
The eTOX Data-Sharing Project to Advance in Silico Drug-Induced Toxicity Prediction
Montserrat Cases,Katharine Briggs,Thomas Steger-Hartmann,Francois Pognan,Philippe Marc,Thomas Kleinöder,Christof H. Schwab,Manuel Pastor,Jörg D. Wichard,Ferran Sanz +9 more
TL;DR: The efforts undertaken to allow effective data sharing intellectual property protection and set up of adequate controlled vocabularies are described and the status of predictive models building and some specific features of the eTOX predictive system are presented as decision support knowledge-based tools for drug development process at an early stage.
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Legacy data sharing to improve drug safety assessment: the eTOX project.
Ferran Sanz,Francois Pognan,Thomas Steger-Hartmann,Carlos Díaz,eTOX,Montserrat Cases,Manuel Pastor,Philippe Marc,Joerg Wichard,Katharine Briggs,David K. Watson,Thomas Kleinöder,Chihae Yang,Alexander Amberg,Maria Beaumont,Anthony J. Brookes,Søren Brunak,Mark T. D. Cronin,Gerhard F. Ecker,Sylvia Escher,Nigel Greene,Antonio Guzmán,Anne Hersey,Pascale Jacques,Lieve Lammens,Jordi Mestres,Wolfgang Muster,Helle Northeved,Marc Pinches,Javier Saiz,Nicolas Sajot,Alfonso Valencia,Johan van der Lei,Nico P. E. Vermeulen,Esther Vock,Gerhard Wolber,Ismael Zamora +36 more
TL;DR: The experience of the eTOX project is discussed, which was established through the Innovative Medicines Initiative to explore the sharing of legacy preclinical safety data among pharmaceutical companies and its integration with other information sources.
Integrative Modeling Strategies for Predicting Drug Toxicities at the eTOX Project
Ferran Sanz,Pau Carrió,Oriol López,Luigi Capoferri,Derk P. Kooi,Nico P. E. Vermeulen,Daan P. Geerke,Floriane Montanari,Gerhard F. Ecker,Christof H. Schwab,Thomas Kleinöder,Tomasz Magdziarz,Manuel Pastor +12 more
TL;DR: An integrative modeling strategy based on these ideas that guided the design of eTOXsys, the prediction system used by the eTOx project is described, which consists of a central server that marshals requests to a collection of independent prediction models and offers a single user interface to the whole system.
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COSMOS DB as an international share point for exchanging regulatory and toxicity data of cosmetics ingredients and related substances
Chihae Yang,Danail Hristozov,Aleksey Tarkhov,Thomas Kleinöder,I. Boyer,Mark T. D. Cronin,Elena Fioravanzo,H. Kim,B. Heldreth,A. Mostrag-Szylchtying,James F. Rathman,Andrea-Nicole Richarz,Christof H. Schwab,Vessela Vitcheva,Andrew Worth +14 more
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Decision support systems for chemical structure representation, reaction modeling, and spectra simulation
Johann Gasteiger,S. Bauerschmidt,U. Burkard,Markus C. Hemmer,Achim Herwig,A. von Homeyer,Robert Höllering,Thomas Kleinöder,Thomas Kostka,Christof H. Schwab,Paul Selzer,L. Steinhauer +11 more
TL;DR: The EROS system for the simulation of chemical reactions is briefly presented and its application to the degradation of s -triazine herbicides is shown.
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