Thomas Jung
University of Göttingen
10 Papers
205 Citations
Thomas Jung is an academic researcher from University of Göttingen. The author has contributed to research in topics: Interleukin 21 & Interleukin 4. The author has an hindex of 9, co-authored 10 publications.
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Papers
Interleukin‐13 is produced by activated human CD45RA+ and CD45R0+ T cells: modulation by interleukin‐4 and interleukin‐12
TL;DR: Analysis of intracellular cytokine production by single CD45RA+ and CD45R0+ T cells indicated that IL‐13 continued to be produced for more than 24 h after stimulation, whereas IL‐4 could not be detected after 24 h, suggesting thatIL‐13 may have IL‐ 4‐like functions in situations where T cell‐derived IL‐3 is still absent or where its production has already been down‐regulated.
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Epidermal Cytokines IL-1β, TNF-α, and IL-12 in Patients with Atopic Dermatitis: Response to Application of House Dust Mite Antigens1
TL;DR: Comparing epidermal cytokines in the skin of patients who developed a positive allergen patch test to those who stayed negative, suggests that only expression of IL-1β mRNA may be a predictive marker for the development of a positive patch test reaction to HDM.
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Interleukin-4 and interleukin-5 are rarely co-expressed by human T cells
Thomas Jung,Uwe Schauer,Christian H.L. Rieger,Kathrin Wagner,Karin Einsle,Christine Neumann,Christoph Heusser +6 more
TL;DR: It is concluded that the simultaneous production of IL‐4 and IL‐5 is a feature of repetitively activated human T cells after prolonged stimulation with a minimum of two restimulation cycles.
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Enhancement of human IL-4 activity by soluble IL-4 receptors in vitro.
TL;DR: It is shown that human recombinant sIL‐4R induced the formation of complexed IL‐4 in supernatants of activated T cells in a dose‐dependent manner as measured by newly developed enzyme‐linked immunosorbent assays.
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Human keratinocytes constitutively express IL-4 receptor molecules and respond to IL-4 with an increase in B7/BB1 expression.
TL;DR: It is suggested that locally produced IL‐4, besides modulating keratinocyte membrane molecules, may enable keratinoeytes to interact with skin infiltrating lymphocytes.
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