Thomas J. Reilly
University of Missouri
48 Papers
302 Citations
Thomas J. Reilly is an academic researcher from University of Missouri. The author has contributed to research in topics: Acid phosphatase & Francisella tularensis. The author has an hindex of 18, co-authored 46 publications. Previous affiliations of Thomas J. Reilly include University of Illinois at Urbana–Champaign.
Chat about Author
Papers
NadN and e (P4) are essential for utilization of NAD and nicotinamide mononucleotide but not nicotinamide riboside in Haemophilus influenzae.
Gabriele Kemmer,Thomas J. Reilly,Joachim Schmidt-Brauns,Gary W. Zlotnik,Bruce A. Green,Michael J. Fiske,Mark Herbert,Anita Kraiß,Stefan Schlör,Arnold L. Smith,Joachim Reidl +10 more
TL;DR: The functions and substrates of these two proteins as they act together in an NAD utilization pathway are described, which indicate that NadN harbors not only NAD pyrophosphatase but also NMN 5'-nucleotidase activity.
80
Combined deletion of four Francisella novicida acid phosphatases attenuates virulence and macrophage vacuolar escape.
TL;DR: The goal of this study was to delete the four primary acid phosphatases (Acps) from Francisella novicida and examine the interactions of mutant strains with macrophages, as well as the virulence of these strains in mice.
75
Initial Proteome Analysis of Model Microorganism Haemophilus influenzae Strain Rd KW20
Eugene Kolker,Samuel O. Purvine,Michael Y. Galperin,Serg Stolyar,David R. Goodlett,Alexey I. Nesvizhskii,Andrew Keller,Tao Xie,Jimmy K. Eng,Eugene C. Yi,Leroy Hood,Alex F. Picone,Tim Cherny,Brian Tjaden,Andrew F. Siegel,Thomas J. Reilly,Kira S. Makarova,Bernhard O. Palsson,Arnold L. Smith +18 more
TL;DR: The direct proteomics approach to studying protein expression in vivo reported here is a powerful method that is applicable to proteome analysis of any (micro)organism.
74
Francisella Acid Phosphatases Inactivate the NADPH Oxidase in Human Phagocytes
Nrusingh P. Mohapatra,Shilpa Soni,Murugesan V. S. Rajaram,Pham My-Chan Dang,Pham My-Chan Dang,Thomas J. Reilly,Jamel El-Benna,Jamel El-Benna,Corey D. Clay,Larry S. Schlesinger,John S. Gunn +10 more
TL;DR: Francisella acid phosphatases play a major role in intramacrophage survival and virulence by regulating the generation of the oxidative burst in human phagocytes through regulation of NADPH oxidase inhibitor or within macrophages isolated from p47phox knockout mice.
The Biological Buffer, Bicarbonate/CO2, Potentiates H2O2-Mediated Inactivation of Protein Tyrosine Phosphatases
Haiying Zhou,Harkewal Singh,Zachary D. Parsons,Sarah M. Lewis,Sanjib Bhattacharya,Derrick R. Seiner,Jason N. LaButti,Thomas J. Reilly,John J. Tanner,Kent S. Gates +9 more
TL;DR: Evidence is presented that the biological buffer bicarbonate/CO(2) potentiates the ability of H( 2)O(2), or peroxymonocarbonate, to inactivate PTPs.