Thomas J. Begley
University at Albany, SUNY
102 Papers
871 Citations
Thomas J. Begley is an academic researcher from University at Albany, SUNY. The author has contributed to research in topics: Transfer RNA & DNA damage. The author has an hindex of 37, co-authored 84 publications. Previous affiliations of Thomas J. Begley include Massachusetts Institute of Technology & State University of New York System.
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Papers
Diameter dependent degradation of single walled carbon nanotubes
Abhishek Gottipati,James H. Keith,Nithin Nedumthakady,Thomas J. Begley,Scott A. Tenenbaum +4 more
- 25 Apr 2014
TL;DR: In this paper, the degradation of single walled carbon nanotubes via chemical method (3:1 ratio of sulfuric acid to nitric acid) and enzymatic method by Horseradish peroxidase (HRP) was investigated.
1
Base Pairing and Functional Insights into N3-methylcytidine (m3C) in RNA
Song Mao,Phensinee Haruehanroengra,Srivathsan V. Ranganathan,Fusheng Shen,Thomas J. Begley,Jia Sheng +5 more
TL;DR: The biochemical investigation of m3C using reverse transcription shows that N3-methylation specifies the C:A pair and induces a G to A mutation using HIV-1-RT, MMLV-RT and MutiScribe™-RT enzymes, all with relatively low replication fidelity.
3rd US-EU workshop: systems level understanding of DNA damage responses.
Miriam Sander,Thomas J. Begley,Christian Desaintes,Anne-Claude Gavin,Richard Pelroy,Joris Pothof,Yossef Shiloh,Dik van Gent,Ben Van Houten,Michael B. Yaffe,Leon Mullenders +10 more
TL;DR: This third meeting in 2009 refined the role of DDR networks in human disease and established the basis for a reciprocal scientific exchange program between the EU and US in the relevant areas of DDR research.
1
Epitranscriptomic reprogramming is required to prevent stress and damage from acetaminophen
TL;DR: In this article, the authors define how acetaminophen (APAP) induces epitranscriptomic reprogramming and how the writer Alkylation Repair Homolog 8 (Alkbh8) plays a key gene regulatory role in the response.
Epitranscriptomic regulation of the response to the air pollutant naphthalene in mouse lungs: From the perspectives of specialized translation and tolerance linked to the writer ALKBH8
Andrea Leonardi,Nataliia Kovalchuk,Lei Yin,Lauren Endres,Lauren Endres,Sara Evke,Steven Nevins,Samuel Martin,Peter C. Dedon,Peter C. Dedon,J. Andres Melendez,J. Andres Melendez,Laura S. Van Winkle,Qing Yu Zhang,Xinxin Ding,Thomas J. Begley +15 more
TL;DR: It is concluded that the epitranscriptomic writer ALKBH8 plays a protective role against NA-induced lung dysfunction and promotes NA tolerance, providing an early example of how epitranscriptionomic systems can regulate the response to environmental stress in vivo.