Thomas J. Begley
University at Albany, SUNY
102 Papers
871 Citations
Thomas J. Begley is an academic researcher from University at Albany, SUNY. The author has contributed to research in topics: Transfer RNA & DNA damage. The author has an hindex of 37, co-authored 84 publications. Previous affiliations of Thomas J. Begley include Massachusetts Institute of Technology & State University of New York System.
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Papers
Queuine is a nutritional regulator of Entamoeba histolytica response to oxidative stress and a virulence attenuator
Shruti Nagaraja,Maggi W. Cai,Maggi W. Cai,Jingjing Sun,Hugo Varet,Lotem Sarid,Meirav Trebicz-Geffen,Yana Shaulov,Mohit Mazumdar,Rachel Legendre,Jean-Yves Coppée,Thomas J. Begley,Peter C. Dedon,Peter C. Dedon,Samudrala Gourinath,Nancy Guillén,Nancy Guillén,Yumiko Saito-Nakano,Chikako Shimokawa,Hajime Hisaeda,Serge Ankri +20 more
TL;DR: The data reveal that queuine plays a dual role in promoting OS resistance and reducing parasite virulence, and may lead to new strategies for preventing and/or treating amebiasis by providing to the host queuine directly or via probiotics.
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The DNA-damage signature in Saccharomyces cerevisiae is associated with single-strand breaks in DNA.
Rebecca C. Fry,Michael S. DeMott,Joseph P. Cosgrove,Joseph P. Cosgrove,Thomas J. Begley,Leona D. Samson,Peter C. Dedon +6 more
TL;DR: Dissection of the transcriptional response in yeast that is specifically signaled by DNA strand breaks has identified that single-strand breaks provide the signal for activation of transcripts encoding proteins involved in the DNA damage signature in S. cerevisiae, and double-Strand breaks signal changes in cell cycle regulation genes.
Transcriptional networks in S. cerevisiae linked to an accumulation of base excision repair intermediates.
Ivan Rusyn,Rebecca C. Fry,Thomas J. Begley,Joanna Klapacz,J. Peter Svensson,Mark Ambrose,Leona D. Samson +6 more
TL;DR: Results suggest that a branch point exists in the current model for DNA damage-signaled transcription in S. cerevisiae, and highlight that DNA damage in the form of abasic sites or strand breaks resulting from BER modulation is a trigger for substantial genome-wide change.
Anc1, a Protein Associated with Multiple Transcription Complexes, Is Involved in Postreplication Repair Pathway in S. cerevisiae
Rachel L. Erlich,Rebecca C. Fry,Thomas J. Begley,Danielle L. Daee,Robert S. Lahue,Leona D. Samson +5 more
TL;DR: It is shown that ANC1 is in the same epistasis group as SRS2 and RAD5, members of the postreplication repair (PRR) pathway, but has additive or synergistic interactions with several other members of this pathway.
The absence of the queuosine tRNA modification leads to pleiotropic phenotypes revealing perturbations of metal and oxidative stress homeostasis in Escherichia coli K12
Leticia Pollo-Oliveira,Nick Davis,Intekhab Hossain,Peiying Ho,Yifeng Yuan,Pedro Salguero Garcia,Cécile Pereira,Shane Byrne,Jiapeng Leng,Melody Sze,Crysten E. Blaby-Haas,Agnieszka Sekowska,A. Barba Montoya,Thomas J. Begley,Antoine Danchin,Daniel P. Aalberts,Alexander Angerhofer,John Hunt,Ana Conesa,Peter C. Dedon,Valérie de Crécy-Lagard +20 more
TL;DR: Downstream analysis of the transcriptomic data suggested that the absence of Q triggers an atypical oxidative stress response, confirmed by the detection of slightly elevated reactive oxygen species (ROS) levels in the mutant, increased sensitivity to hydrogen peroxide and paraquat, and a subtle growth phenotype in a strain prone to accumulation of ROS.
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