Thomas Hofmann
University of Jena
7 Papers
92 Citations
Thomas Hofmann is an academic researcher from University of Jena. The author has contributed to research in topics: Butyrate & HT29 Cells. The author has an hindex of 7, co-authored 7 publications.
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Papers
Mechanisms of primary cancer prevention by butyrate and other products formed during gut flora-mediated fermentation of dietary fibre
Daniel Scharlau,Anke Borowicki,Nina Habermann,Thomas Hofmann,Stefanie Klenow,Claudia Miene,Umang Munjal,Katrin Stein,Michael Glei +8 more
TL;DR: Dietary fibres are indigestible food ingredients that reach the colon and are then fermented by colonic bacteria, resulting mainly in the formation of short-chain fatty acids (SCFA), which can reduce the burden of carcinogens and decrease the number of mutations, reducing cancer risk.
345
Both wheat (Triticum aestivum) bran arabinoxylans and gut flora-mediated fermentation products protect human colon cells from genotoxic activities of 4-hydroxynonenal and hydrogen peroxide.
Michael Glei,Thomas Hofmann,Katrin Kuster,Jürgen Hollmann,Meinolf Georg Lindhauer,Beatrice L. Pool-Zobel +5 more
TL;DR: In this paper, the effects of wheat bran derived arabinoxylans and fermentation products on these parameters of chemoprevention were investigated, and the conclusion is that fermentation mixtures contain modulatory compounds that arise from the feces and might add to the effectiveness of SCFAs.
71
Modulation of detoxification enzymes by watercress: in vitro and in vivo investigations in human peripheral blood cells
Thomas Hofmann,A. Kuhnert,A. Schubert,Chris I R Gill,Ian Rowland,Beatrice L. Pool-Zobel,Michael Glei +6 more
TL;DR: The results indicate that WC is able to modulate the enzymes SOD and GPX in blood cells in vitro and in vivo, and suggest that the capacity of moderate intake of CV to induce detoxification is dependent in part on the GSTM1 genotype.
41
Intervention with polyphenol-rich fruit juices results in an elevation of glutathione S-transferase P1 (hGSTP1) protein expression in human leucocytes of healthy volunteers
Thomas Hofmann,U.M. Liegibel,Peter Winterhalter,Achim Bub,Gerhard Rechkemmer,Beatrice L. Pool-Zobel +5 more
TL;DR: In vitro treatment of leucocytes led to a modulated mRNA expression of selected genes, not directly related to oxidative defence systems, but in an up-regulation of other biotransformation enzymes (e. g., members of the cytochrome P450 and the sulphotransferase family).
27
Gene expression profiles in human peripheral blood mononuclear cells as biomarkers for nutritional in vitro and in vivo investigations
Thomas Hofmann,Stefanie Klenow,Anke Borowicki,Chris I R Gill,Beatrice L. Pool-Zobel,Michael Glei +5 more
TL;DR: It is concluded that peripheral blood mononuclear cells may serve as a surrogate tissue in dietary investigations and the identified differentially expressed genes have the potential to become marker genes for population studies on biological effects.