Thomas Hof
University of Bordeaux
19 Papers
1 Citations
Thomas Hof is an academic researcher from University of Bordeaux. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 9, co-authored 13 publications. Previous affiliations of Thomas Hof include Columbia University & University of Caen Lower Normandy.
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Papers
Transient receptor potential channels in cardiac health and disease.
Thomas Hof,Sébastien Chaigne,Sébastien Chaigne,A Recalde,A Recalde,Laurent Sallé,F. Brette,F. Brette,Romain Guinamard +8 more
TL;DR: The authors summarize the various physiological and pathological cardiac processes in which TRP channels are involved and discuss their contribution to pathophysiological mechanisms, which will help to identify the best candidates for new therapeutic targets among the cardiac TRP family.
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The TRPM4 channel inhibitor 9-phenanthrol
TL;DR: 9‐phenanthrol modulates smooth muscle contraction in bladder and cerebral arteries, affects spontaneous activity in neurons and in the heart, and reduces lipopolysaccharide‐induced cell death, and thus exerts beneficial effects in several pathological conditions.
The TRPM4 Non-Selective Cation Channel Contributes to the Mammalian Atrial Action Potential
TL;DR: The results showed that TRPM4 is implicated in the waveform of the atrial action potential and is thus a potential target for pharmacological approaches against atrial arrhythmias.
82
Implication of the TRPM4 nonselective cation channel in mammalian sinus rhythm.
TL;DR: Investigation of spontaneous heart beating in mouse, rat, and rabbit isolated right atria showed that TRPM4 modulates beating rate, which may act against bradycardia.
79
Regulation of IKs Potassium Current by Isoproterenol in Adult Cardiomyocytes Requires Type 9 Adenylyl Cyclase
TL;DR: It is shown that AC9 is the only adenylyl cyclase (AC) isoform associated with the KCNQ1-KCNE1-Yotiao complex in the heart and necessary for sympathetic regulation of PKA phosphorylation of KCNq1 in vivo and for functional regulation of IKs in adult cardiomyocytes.
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