Thomas Hermsdorf
Leipzig University
19 Papers
241 Citations
Thomas Hermsdorf is an academic researcher from Leipzig University. The author has contributed to research in topics: G protein-coupled receptor & Receptor. The author has an hindex of 14, co-authored 19 publications.
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Papers
Mutant G-protein-coupled receptors as a cause of human diseases.
Torsten Schöneberg,Angela Schulz,Heike Biebermann,Thomas Hermsdorf,Holger Römpler,Katrin Sangkuhl +5 more
TL;DR: The current knowledge relevant to understanding the molecular basis of GPCR function is summarized, with primary emphasis on the mechanisms underlying G PCR malfunction responsible for different human diseases.
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Structural and functional evolution of the P2Y12-like receptor group
Torsten Schöneberg,Thomas Hermsdorf,Eva Engemaier,Kathrin M. Engel,Ines Liebscher,Doreen Thor,Klaas Zierau,Holger Römpler,Holger Römpler,Angela Schulz +9 more
TL;DR: The P2Y12-like receptor group comprises several structurally related GPCR which, however, display heterogeneous agonist specificity including nucleotides, their derivatives, and lipids and this review focuses specifically on the structure-function relation.
Involvement of the V2 Vasopressin Receptor in Adaptation to Limited Water Supply
Iris Böselt,Holger Römpler,Holger Römpler,Thomas Hermsdorf,Doreen Thor,Wibke Busch,Angela Schulz,Torsten Schöneberg +7 more
TL;DR: Comparison of over 80 mammalian V2 vasopressin receptor (V2R) orthologs revealed high structural and functional conservation of this key component involved in renal water reabsorption, indicating an essential role of V2R activity for survival even of those species with unlimited access to water.
The ligand specificity of the G-protein-coupled receptor GPR34.
Lars Ritscher,Eva Engemaier,Claudia Stäubert,Ines Liebscher,Philipp Schmidt,Thomas Hermsdorf,Holger Römpler,Angela Schulz,Torsten Schöneberg +8 more
TL;DR: The results of the present study suggest that lyso-PS has only a random agonistic activity at some GPR34 orthologues and the search for the endogenous agonist should consider additional chemical entities.
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Detrusor smooth muscle cells of the guinea-pig are functionally coupled via gap junctions in situ and in cell culture.
TL;DR: The use of smooth muscle cell cultures seems to be a feasible approach for studying coupling behaviour in vitro, as electron-microscopic examination of freeze-fracture specimens and ultrathin sections revealed that the dye-coupling was based on typical gap junction formation between the cultured smooth muscle cells.
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