Thomas Garton
Johns Hopkins University
5 Papers
Thomas Garton is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Multiple sclerosis & Medicine. The author has an hindex of 1, co-authored 3 publications. Previous affiliations of Thomas Garton include Johns Hopkins University School of Medicine.
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Papers
A lymphocyte-microglia-astrocyte axis in chronic active multiple sclerosis.
Martina Absinta,Martina Absinta,Martina Absinta,Dragan Maric,Marjan Gharagozloo,Thomas Garton,Matthew D. Smith,Jing Jin,Kathryn C. Fitzgerald,Anya Song,Poching Liu,Jing-Ping Lin,Tianxia Wu,Kory R. Johnson,Dorian B. McGavern,Dorothy P. Schafer,Peter A. Calabresi,Daniel S. Reich +17 more
TL;DR: In this article, the authors used MRI-informed single-nucleus RNA sequencing to profile the edge of demyelinated white matter lesions at various stages of inflammation and uncovered notable glial and immune cell diversity, especially at the chronically inflamed lesion edge.
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Complement component 3 from astrocytes mediates retinal ganglion cell loss during neuroinflammation
Marjan Gharagozloo,Matthew D. Smith,Jing Jin,Thomas Garton,Michelle Taylor,Alyssa Chao,Keya Meyers,Michael D. Kornberg,Donald J. Zack,Donald J. Zack,Joan Ohayon,Brent A. Calabresi,Daniel S. Reich,Charles G. Eberhart,Carlos A. Pardo,Claudia Kemper,Katharine A. Whartenby,Peter A. Calabresi,Peter A. Calabresi +18 more
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Therapeutic Potential of a Novel Glucagon-like Peptide-1 Receptor Agonist, NLY01, in Experimental Autoimmune Encephalomyelitis.
Marjan Gharagozloo,Matthew D. Smith,Elias S. Sotirchos,Jing Jin,Keya Meyers,Michelle Taylor,Thomas Garton,Riley Bannon,Hannah-Noelle Lord,Ted M. Dawson,Valina L. Dawson,Seulki Lee,Peter A. Calabresi,Peter A. Calabresi +13 more
TL;DR: In this paper, the authors investigated the therapeutic potential of NLY01 in a mouse model of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE), and showed that the anti-inflammatory effect at the early stage of EAE may block the expression of the genes associated with neurotoxic astrocytes in the optic nerve, thereby preventing retinal ganglion cell (RGC) loss in the progressive stage.
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Distinct mechanisms of oligodendrocyte injury inform therapeutic interventions in multiple sclerosis.
TL;DR: In this paper , a scientific commentary refers to the diverse injury responses of human oligodendrocytes to mediators implicated in multiple sclerosis, which is referred to as Pernin et al.
The Effects of NLY01, a Novel Glucagon-Like Peptide-1 Receptor Agonist, on Cuprizone-Induced Demyelination and Remyelination: Challenges and Future Perspectives.
Marjan Gharagozloo,Larissa Jank,Elias S. Sotirchos,Matthew D. Smith,Thomas Garton,Michelle Taylor,C. Siu,Ted M. Dawson,Valina L. Dawson,Seulki Lee,Peter A. Calabresi +10 more
TL;DR: Despite the promising anti-inflammatory and neuroprotective effects of GLP-1R agonists that have been previously described, the experiments provided no evidence to support a beneficial effect of NLY01 on limiting demyelination or enhancing remyelinations.