Thomas Egebjerg
Novo Nordisk
18 Papers
21 Citations
Thomas Egebjerg is an academic researcher from Novo Nordisk. The author has contributed to research in topics: Chemistry & Biology. The author has an hindex of 6, co-authored 14 publications.
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Papers
Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists
Xin Zhang,Matthew J. Belousoff,Peishen Zhao,Albert J. Kooistra,Tin T. Truong,Sheng Y. Ang,Christina Rye Underwood,Thomas Egebjerg,Petr Šenel,Gregory D. Stewart,Yi Lynn Liang,Alisa Glukhova,Hari Venugopal,Arthur Christopoulos,Sebastian G.B. Furness,Laurence J. Miller,Steffen Reedtz-Runge,Christopher J. Langmead,David E. Gloriam,Radostin Danev,Patrick M. Sexton,Denise Wootten +21 more
TL;DR: High-resolution cryo-EM structures reveal that the binding sites for PF 06882961 and GLP-1 substantially overlap, whereas CHU-128 adopts a unique binding mode with a more open receptor conformation at the extracellular face, which will facilitate rational structure-based discovery of non-peptide agonists targeting class B GPCRs.
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A factor VIIIa-mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice.
Henrik Østergaard,Jacob Lund,Per Jr Greisen,Stine Kjellev,A. Henriksen,Nikolai Lorenzen,Eva Johansson,Gustav Røder,Morten Grønbech Rasch,Laust Bruun Johnsen,Thomas Egebjerg,Søren Lund,Henrik Rahbek-Nielsen,Prafull S. Gandhi,Kasper Lamberth,Mette Loftager,Lisbeth Moreau Andersen,Amalie Carnbring Bonde,Fabian Stavenuiter,Daniel Elenius Madsen,Xun Li,Thomas Lindebo Holm,Carsten Dan Ley,Peter Thygesen,Haisun Zhu,Rong Zhou,Karina Thorn,Zhiru Yang,Mette B. Hermit,Jais Rose Bjelke,Bjarne Gram Hansen,Ida Hilden +31 more
TL;DR: Mim8 as mentioned in this paper is an activated FVIII mimetic with a potent and efficacious hemostatic effect based on preclinical data, which is a bispecific antibody assembled with FIXa and FX on membranes, and supported activation with an apparent equilibrium dissociation constant of 16 nM.
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Design of Biopharmaceutical Formulations Accelerated by Machine Learning.
Harini Narayanan,Fabian Dingfelder,Fabian Dingfelder,Itzel Condado Morales,Itzel Condado Morales,Bhargav Patel,Kristine Enemærke Heding,Jais Rose Bjelke,Thomas Egebjerg,Alessandro Butté,Michael Sokolov,Nikolai Lorenzen,Paolo Arosio +12 more
TL;DR: In this article, a Bayesian optimization algorithm was proposed to accelerate the design of biopharmaceutical formulations, which can provide high speed of converging to optimal conditions, the ability to transfer prior knowledge, and the identification of new nonlinear combinations of excipients.
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Distribution and ultrastructural localization of the glucagon-like peptide-1 receptor (GLP-1R) in the rat brain
Erzsébet Farkas,Anett Szilvásy-Szabó,Yvette Ruska,Richárd Sinkó,Morten Grønbech Rasch,Thomas Egebjerg,Charles Pyke,Balázs Gereben,Lotte Bjerre Knudsen,Csaba Fekete +9 more
TL;DR: In this paper, a detailed map of the GLP-1R-IR structures in the rat brain was provided, showing that the highest density of immunoreactivity was observed in the circumventricular organs and regions in the vicinity of these areas like in the arcuate nucleus (ARC) and in the nucleus tractus solitarii (NTS).
Differential GLP-1R binding and activation by peptide and non-peptide agonists
Xin Zhang,Matthew J. Belousoff,Peishen Zhao,Albert J. Kooistra,Tin T. Truong,Sheng Y. Ang,Christina Rye Underwood,Thomas Egebjerg,Petr Šenel,Gregory D. Stewart,Yi Lynn Liang,Alisa Glukhova,Hari Venugopal,Arthur Christopoulos,Sebastian G.B. Furness,Laurence J. Miller,Steffen Reedtz-Runge,Christopher J. Langmead,David E. Gloriam,Radostin Danev,Patrick M. Sexton,Denise Wootten +21 more
TL;DR: High resolution cryo-EM structures reveal the binding sites for PF-06882961 and GLP-1 substantially overlap, whereas OWL-833 adopts a unique binding mode with a more open receptor conformation at the extracellular face, which will facilitate rational structure-based discovery of non-peptide agonists targeting class B GPCRs.