Thomas E.F. Webb
University College Hospital
9 Papers
75 Citations
Thomas E.F. Webb is an academic researcher from University College Hospital. The author has contributed to research in topics: PRNP & Age of onset. The author has an hindex of 8, co-authored 9 publications. Previous affiliations of Thomas E.F. Webb include University of Cambridge & UCL Institute of Neurology.
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Papers
Phenotypic heterogeneity and genetic modification of P102L inherited prion disease in an international series
Thomas E.F. Webb,Mark Poulter,John Beck,James Uphill,Gary Adamson,Thomas B. Campbell,Jacqueline M. Linehan,Caroline Powell,Sebastian Brandner,Suvankar Pal,D. Siddique,Jonathan D. F. Wadsworth,Susan Joiner,K. Alner,C. Petersen,S. Hampson,C. Rhymes,Colm Treacy,Elsdon Storey,Michael D. Geschwind,Andrea H. Németh,Stephen J. Wroe,John Collinge,Simon Mead +23 more
TL;DR: Data from 84 patients in the large UK kindred and numerous small unrelated pedigrees is collected to investigate phenotypic heterogeneity and modifying factors and shows that polymorphic human prion protein gene codon 129 modifies age at onset, showing an appreciation of the range of clinical phenotype, modern imaging and molecular investigation and should inform genetic counselling of at-risk individuals.
Inherited prion disease with six octapeptide repeat insertional mutation--molecular analysis of phenotypic heterogeneity.
Simon Mead,Mark Poulter,Jon Beck,Thomas E.F. Webb,Tracy Campbell,Jacqueline M. Linehan,Melanie Desbruslais,Susan Joiner,Jonathan D. F. Wadsworth,Andy King,Peter L. Lantos,John Collinge +11 more
TL;DR: The effect of PrP genotype, candidate genes and prion strain type on clinical, neuroradiological and neuropathological phenotype, and transmission characteristics of prions from affected individuals resembled those of classical sporadic Creutzfeldt-Jakob disease.
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Lack of TAR-DNA binding protein-43 (TDP-43) pathology in human prion diseases
Adrian M. Isaacs,Caroline Powell,Thomas E.F. Webb,Jacqueline M. Linehan,John Collinge,Sebastian Brandner +5 more
TL;DR: These data do not support a role for TDP‐43 in prion disease pathogenesis and argue that TDP•43 inclusions define a distinct group of neurodegenerative disorders.
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Age of onset and death in inherited prion disease are heritable.
TL;DR: The correlation of age at onset and death, expressed as a composite Z score, between parents and offspring in three large UK inherited prion disease kindreds is investigated to suggest a significant heritable component to phenotypic variability and support attempts to identify human prions disease modifier genes.
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Sequence homology between human PARP14 and the SARS-CoV-2 ADP ribose 1'-phosphatase.
Thomas E.F. Webb,Ramy Saad +1 more
TL;DR: There is amino acid sequence homology between the ADP-ribose binding sites of human PARP14 and SARS-CoV-2 ADRP and the model proposed highlights the potential of the PARP axis to yield druggable targets for the treatment of COVID-19.
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