Thomas D. Geracioti
University of Cincinnati Academic Health Center
93 Papers
1K Citations
Thomas D. Geracioti is an academic researcher from University of Cincinnati Academic Health Center. The author has contributed to research in topics: Corticotropin-releasing hormone & Internal medicine. The author has an hindex of 37, co-authored 91 publications. Previous affiliations of Thomas D. Geracioti include University of Chicago & Veterans Health Administration.
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Papers
Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropin-releasing hormone.
Ma-Li Wong,Mitchel A. Kling,Peter J. Munson,Samuel J. Listwak,Julio Licinio,Paolo Prolo,Brian Karp,Ian E. McCutcheon,Thomas D. Geracioti,Michael D. DeBellis,K. C. Rice,David S. Goldstein,Johannes D. Veldhuis,George P. Chrousos,Edward H. Oldfield,Samuel M. McCann,Philip W. Gold +16 more
TL;DR: The data indicate that persistent stress-system dysfunction in melancholic depression is independent of the conscious stress of the disorder and suggest mutually reinforcing bidirectional links between a central hypernoradrenergic state and the hyperfunctioning of specific central CRH pathways that each are driven and sustained by hypercortisolism.
601
Serial CSF corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorder.
Dewleen G. Baker,Scott A. West,Wendall E. Nicholson,Nosa N. Ekhator,John Kasckow,Kelly K. Hill,Ann B. Bruce,David N. Orth,Thomas D. Geracioti +8 more
TL;DR: High basal CSF CRH concentrations and normal 24-hour urinary-free cortisol excretion in combat veterans with PTSD, a combination that appears to be unique among psychiatric conditions studied to date are found.
531
CSF norepinephrine concentrations in posttraumatic stress disorder.
Thomas D. Geracioti,Dewleen G. Baker,Nosakhare N. Ekhator,Scott A. West,Kelly K. Hill,Ann B. Bruce,Dennis E. Schmidt,Barbara A. Rounds-Kugler,Rachel Yehuda,Paul E. Keck,John Kasckow +10 more
TL;DR: Findings reveal the presence of greater CNS noradrenergic activity under baseline conditions in patients with chronic PTSD than in healthy subjects and directly link this pathophysiologic observation with the severity of the clinical posttraumatic stress syndrome.
479
Effect of childhood physical abuse on cortisol stress response
Linda L. Carpenter,Thaddeus T. Shattuck,Audrey R. Tyrka,Thomas D. Geracioti,Lawrence H. Price +4 more
TL;DR: In a non-clinical sample of women with minimal or no current psychopathology, physical abuse is associated with a blunted cortisol response to a psychosocial stress task.
329
Noradrenergic dysfunction and the psychopharmacology of posttraumatic stress disorder
TL;DR: Studies of central noreadrenergic hyperactivity under both basal and challenge conditions are reviewed and the evidence for these derangements as potential psychopharmacologic targets in patients with PTSD is explored.
309