Thomas Botton
University of California, San Francisco
19 Papers
98 Citations
Thomas Botton is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Melanoma & Biology. The author has an hindex of 15, co-authored 19 publications. Previous affiliations of Thomas Botton include French Institute of Health and Medical Research & University of Nice Sophia Antipolis.
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Papers
CNVkit: Genome-Wide Copy Number Detection and Visualization from Targeted DNA Sequencing
TL;DR: A method for copy number detection, implemented in the software package CNVkit, that uses both the targeted reads and the nonspecifically captured off-target reads to infer copy number evenly across the genome, successfully inferred copy number at equivalent to 100-kilobase resolution genome-wide from a platform targeting as few as 293 genes.
Kinase fusions are frequent in Spitz tumours and spitzoid melanomas.
Thomas Wiesner,Jie He,Roman Yelensky,Rosaura Esteve-Puig,Thomas Botton,Iwei Yeh,Doron Lipson,Geoff Otto,Kristina W. Brennan,Rajmohan Murali,Maria C. Garrido,Vincent A. Miller,Jeffrey S. Ross,Michael F. Berger,Alyssa J. Sparatta,Gabriele Palmedo,Lorenzo Cerroni,Klaus J. Busam,Heinz Kutzner,Maureen T. Cronin,Philip J. Stephens,Boris C. Bastian,Boris C. Bastian +22 more
TL;DR: It is shown that spitzoid neoplasms harbour kinase fusions of ROS1 (17%), NTRK1 (16%), ALK (10%), BRAF (5%) and RET (3%) in a mutually exclusive pattern and may serve as therapeutic targets for metastatic spitzoids melanomas.
Metformin inhibits melanoma development through autophagy and apoptosis mechanisms
Tomic T,Thomas Botton,Thomas Botton,Michael Cerezo,Michael Cerezo,Guillaume Robert,Guillaume Robert,Frederic Luciano,Frederic Luciano,Alexandre Puissant,Alexandre Puissant,Pierre Gounon,Maryline Allegra,Maryline Allegra,Corine Bertolotto,Corine Bertolotto,Bereder Jm,Sophie Tartare-Deckert,Sophie Tartare-Deckert,Philippe Bahadoran,Philippe Bahadoran,Patrick Auberger,Patrick Auberger,Robert Ballotti,Robert Ballotti,Stéphane Rocchi,Stéphane Rocchi +26 more
TL;DR: The data suggest that metformin has an important impact on melanoma growth, and may therefore be beneficial in patients with melanoma.
Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway.
A. Hunter Shain,Maria C. Garrido,Thomas Botton,Eric Talevich,Iwei Yeh,J. Zachary Sanborn,Jongsuk Chung,Nicholas J. Wang,Hojabr Kakavand,Graham J. Mann,John F. Thompson,John F. Thompson,Thomas Wiesner,Ritu Roy,Adam B. Olshen,Alexander Gagnon,Joe W. Gray,Nam Huh,Joe S Hur,Klaus J. Busam,Richard A. Scolyer,Richard A. Scolyer,Raymond J. Cho,Rajmohan Murali,Boris C. Bastian +24 more
TL;DR: High mutation burden ranked desmoplastic melanoma among the most highly mutated cancers, and genetic alterations known to activate the MAPK and PI3K signaling cascades were identified in 73% of samples, affecting NF1, CBL, ERBB2, MAP2k1, MAP3K1, BRAF, EGFR, PTPN11, MET, RAC1, SOS2, NRAS and PIK3CA.
NTRK3 kinase fusions in Spitz tumours.
Iwei Yeh,Meng Kian Tee,Thomas Botton,A. Hunter Shain,Alyssa J. Sparatta,Alexander Gagnon,Swapna S. Vemula,Maria C. Garrido,Kenji Nakamaru,Takeshi Isoyama,Timothy H. McCalmont,Philip E. LeBoit,Boris C. Bastian +12 more
TL;DR: NTRK3 fusions expand the range of oncogenic kinase fusions in melanocytic neoplasms and offer targets for a small subset of melanomas for which no targeted options currently exist.