Thomas Blank
University of Freiburg
72 Papers
647 Citations
Thomas Blank is an academic researcher from University of Freiburg. The author has contributed to research in topics: Microglia & Biology. The author has an hindex of 32, co-authored 67 publications. Previous affiliations of Thomas Blank include University of Münster & Max Planck Society.
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Papers
Innate immune memory in the brain shapes neurological disease hallmarks
Ann-Christin Wendeln,Ann-Christin Wendeln,Karoline Degenhardt,Karoline Degenhardt,Lalit Kaurani,Lalit Kaurani,Michael Gertig,Michael Gertig,Thomas Ulas,Gaurav Jain,Jessica Wagner,Jessica Wagner,Lisa M. Häsler,Lisa M. Häsler,Katleen Wild,Katleen Wild,Angelos Skodras,Angelos Skodras,Thomas Blank,Ori Staszewski,Moumita Datta,Tonatiuh Pena Centeno,Vincenzo Capece,Md. Rezaul Islam,Cemil Kerimoglu,Matthias Staufenbiel,Matthias Staufenbiel,Joachim L. Schultze,Joachim L. Schultze,Marc Beyer,Marco Prinz,Mathias Jucker,Mathias Jucker,Andre Fischer,Andre Fischer,Jonas J. Neher,Jonas J. Neher +36 more
TL;DR: It is demonstrated that peripherally applied inflammatory stimuli induce acute immune training and tolerance in the brain and lead to differential epigenetic reprogramming of brain-resident macrophages (microglia) that persists for at least six months.
Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System.
Julia Bruttger,Khalad Karram,Simone Wörtge,Tommy Regen,Federico Marini,Nicola Hoppmann,Matthias Klein,Thomas Blank,Simon Yona,Yochai Wolf,Matthias Mack,Emmanuel Pinteaux,Werner Müller,Frauke Zipp,Harald Binder,Tobias Bopp,Marco Prinz,Steffen Jung,Ari Waisman +18 more
TL;DR: It was found that the microglial compartment was reconstituted within 1 week of depletion, and microglia have the potential for efficient self-renewal without the contribution of peripheral myeloid cells, and IL-1R signaling participates in this restorative proliferation process.
572
National Identity in a United Germany: Nationalism or Patriotism? An Empirical Test With Representative Data
Thomas Blank,Peter Schmidt +1 more
TL;DR: The authors investigated the ways in which nationalism and patriotism are related to attitudes toward minorities and found that both East and West Germans displayed attitudinal patterns that link national identity with tolerance toward others.
528
Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions.
Marius Schwabenland,Henrike Salié,Jovan Tanevski,Saskia Killmer,Marilyn Salvat Lago,Alexandra Emilia Schlaak,Lena Sophie Mayer,Jakob Matschke,Klaus Püschel,Antonia Fitzek,Benjamin Ondruschka,Henrik E. Mei,Tobias Boettler,Christoph Neumann-Haefelin,Maike Hofmann,Angele Breithaupt,Nafiye Genc,Christine Stadelmann,Julio Saez-Rodriguez,Peter Bronsert,Klaus-Peter Knobeloch,Thomas Blank,Robert Thimme,Markus Glatzel,Marco Prinz,Bertram Bengsch,Bertram Bengsch +26 more
TL;DR: In this paper, the brain stems and olfactory bulbs in postmortem patients who had COVID-19 using imaging mass cytometry to understand the local immune response at a spatially resolved, high-dimensional, single-cell level and compared their immune map to non-COVID respiratory failure, multiple sclerosis, and control patients.
289
Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease
Daniel Erny,Nikolaos Dokalis,Charlotte Mezö,Angela Castoldi,Omar Mossad,Ori Staszewski,Maximilian Frosch,Matteo Villa,Vidmante Fuchs,Arun Mayer,Jana Neuber,Janika Sosat,Stefan Tholen,Oliver Schilling,Andreas Vlachos,Thomas Blank,Mercedes Gomez de Agüero,Andrew J. Macpherson,Edward J. Pearce,Edward J. Pearce,Marco Prinz +20 more
TL;DR: This paper found that the immature phenotype of microglia from germ-free (GF) mice is epigenetically imprinted by H3K4me3 and H3k9ac on metabolic genes associated with substantial functional alterations including increased mitochondrial mass and specific respiratory chain dysfunctions.
287