Thomas B. Knudsen
United States Environmental Protection Agency
131 Papers
1K Citations
Thomas B. Knudsen is an academic researcher from United States Environmental Protection Agency. The author has contributed to research in topics: Biology & Developmental toxicity. The author has an hindex of 48, co-authored 125 publications. Previous affiliations of Thomas B. Knudsen include Research Triangle Park & University of Louisville.
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Papers
Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function.
Vassilios Papadopoulos,Mario Baraldi,Tomás R. Guilarte,Thomas B. Knudsen,Jean Jacques Lacapère,Peter Lindemann,Michael D. Norenberg,David J. Nutt,Abraham Weizman,Ming Rong Zhang,Moshe Gavish +10 more
TL;DR: Translocator protein (18kDa) is proposed as a new name, regardless of the subcellular localization of the protein, to represent more accurately its sub cellular role (or roles) and putative tissue-specific function (or functions).
1.3K
Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework
Edward J. Calabrese,Kenneth Bachmann,A. John Bailer,P. Michael Bolger,Jonathan Borak,Lu Cai,Nina Cedergreen,M. George Cherian,Chuang Chin Chiueh,Thomas W. Clarkson,Ralph R. Cook,David M. Diamond,David J. Doolittle,Michael A. Dorato,Stephen O. Duke,Ludwig E. Feinendegen,Donald E. Gardner,Ronald W. Hart,Kenneth L. Hastings,A. Wallace Hayes,George R. Hoffmann,John A. Ives,Zbigniew Jaworowski,Thomas E. Johnson,Wayne B. Jonas,Norbert E. Kaminski,John G. Keller,James E. Klaunig,Thomas B. Knudsen,Walter J. Kozumbo,Teresa Lettieri,Shu Zheng Liu,Andre Maisseu,Kenneth I. Maynard,Edward J. Masoro,Roger O. McClellan,Harihara M. Mehendale,Carmel Mothersill,David B. Newlin,Herbert N. Nigg,Frederick W. Oehme,Robert F. Phalen,Martin A. Philbert,Suresh I. S. Rattan,Jim E. Riviere,Joseph Rodricks,Robert M. Sapolsky,Bobby R. Scott,Colin Seymour,David A. Sinclair,Joan Smith-Sonneborn,Elizabeth T. Snow,Linda P. Spear,Donald E. Stevenson,Yolene Thomas,Maurice Tubiana,Gary M. Williams,Mark P. Mattson +57 more
TL;DR: This article offers a set of recommendations that scientists believe can achieve greater conceptual harmony in dose-response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.
735
ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology
Ann M. Richard,Richard S. Judson,Keith A. Houck,Christopher M. Grulke,Patra Volarath,Inthirany Thillainadarajah,Chihae Yang,James F. Rathman,Matthew T. Martin,John F. Wambaugh,Thomas B. Knudsen,Jayaram Kancherla,Kamel Mansouri,Grace Patlewicz,Antony J. Williams,Stephen B. Little,Kevin M. Crofton,Russell S. Thomas +17 more
TL;DR: The ToxCast chemical library is demonstrated to provide comprehensive coverage of the knowledge domains and target inventories of potential interest to EPA, and the varied representations and approaches presented here define local chemistry domains potentially worthy of further investigation.
627
In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project
Richard S. Judson,Keith A. Houck,Robert J. Kavlock,Thomas B. Knudsen,Matthew T. Martin,Holly M. Mortensen,David M. Reif,Daniel M. Rotroff,Imran Shah,Ann M. Richard,David J. Dix +10 more
TL;DR: A statistically significant inverse association between the number of pathways perturbed by a chemical at low in vitro concentrations and the lowest in vivo dose at which a chemical causes toxicity is found.
604
Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management
Robert J. Kavlock,Kelly J. Chandler,Keith A. Houck,Sid Hunter,Richard S. Judson,Nicole Kleinstreuer,Thomas B. Knudsen,Matthew T. Martin,Stephanie Padilla,David M. Reif,Ann M. Richard,Daniel M. Rotroff,Nisha S. Sipes,David J. Dix +13 more
TL;DR: A summary of the initial, proof of concept, Phase I of ToxCast that has laid the groundwork for the next phases and future directions of the program is provided.
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