Thiruvur Niranjan
Albert Einstein College of Medicine
8 Papers
27 Citations
Thiruvur Niranjan is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Notch signaling pathway & Glomerulosclerosis. The author has an hindex of 7, co-authored 8 publications. Previous affiliations of Thiruvur Niranjan include University of Pennsylvania & Yeshiva University.
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Papers
The Notch pathway in podocytes plays a role in the development of glomerular disease
Thiruvur Niranjan,Bernhard Bielesz,Antje Gruenwald,Manish P. Ponda,Jeffrey B. Kopp,David B. Thomas,Katalin Susztak +6 more
TL;DR: Observations suggest that Notch activation in mature podocytes is a new mechanism in the pathogenesis of glomerular disease and thus could represent a new therapeutic target.
429
Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans
Bernhard Bielesz,Yasemin Sirin,Yasemin Sirin,Han Si,Thiruvur Niranjan,Antje Gruenwald,Seon-Ho Ahn,Hideki Kato,James Pullman,Manfred Gessler,Volker H. Haase,Katalin Susztak +11 more
TL;DR: It is established that epithelial injury and Notch signaling play key roles in fibrosis development and indicate that Notch blockade may be a therapeutic strategy to reduce fibrosis and ESRD development.
Expression of Notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function
Mariana Murea,Jun Ki Park,Shuchita Sharma,Hideki Kato,Antje Gruenwald,Thiruvur Niranjan,Han Si,David B. Thomas,James Pullman,Michal L. Melamed,Katalin Susztak +10 more
TL;DR: The results raise the possibility that Notch pathway activation is a common mechanism in the pathophysiology of a wide range of acquired renal diseases.
181
Notch1 and notch2 in podocytes play differential roles during diabetic nephropathy development
Mariya T. Sweetwyne,Antje Gruenwald,Thiruvur Niranjan,Ryuichi Nishinakamura,Lothar J. Strobl,Katalin Susztak +5 more
TL;DR: It is reported that conditional deletion of Notch1 in podocytes using NPHS2creNotch1flox/flox animals resulted in marked amelioration of DKD, and studies indicate that Notch 1 plays a distinct (nonredundant) role in podocyte during DKD development.
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The Pathogenic Role of Notch Activation in Podocytes
TL;DR: Genetic studies performed on mice with conditional expression of active Notch1 protein showed massive albuminuria, glomerulosclerosis, and ultimately renal failure and death of the animals, suggesting the activation of Notch pathway in podocytes represents a common pathomechanism in glomerular injury.