Thierry Planchenault
Pasteur Institute
14 Papers
110 Citations
Thierry Planchenault is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Receptor & Fibronectin. The author has an hindex of 11, co-authored 14 publications. Previous affiliations of Thierry Planchenault include French Institute of Health and Medical Research.
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Papers
WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12.
Karl Balabanian,Bernard Lagane,José L. Pablos,Lysiane Laurent,Thierry Planchenault,Olivier Verola,Céleste Lebbé,D. Kerob,Alain Dupuy,Olivier Hermine,Jean-François Nicolas,Véronique Latger-Cannard,Danièle Bensoussan,Pierre Bordigoni,Françoise Baleux,Françoise Le Deist,Jean-Louis Virelizier,Fernando Arenzana-Seisdedos,Françoise Bachelerie +18 more
TL;DR: It is proposed that the sustained CXCR4 activity in patient cells accounts for the immune-hematologic clinical manifestations and the profusion of warts characteristic of the WHIM syndrome.
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CXCR4 dimerization and beta-arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome.
Bernard Lagane,Bernard Lagane,Ken Y.C. Chow,Ken Y.C. Chow,Karl Balabanian,Karl Balabanian,Angélique Levoye,Angélique Levoye,Julie Harriague,Julie Harriague,Thierry Planchenault,Thierry Planchenault,Françoise Baleux,Nathalie Gunera-Saad,Fernando Arenzana-Seisdedos,Fernando Arenzana-Seisdedos,Françoise Bachelerie,Françoise Bachelerie +17 more
TL;DR: This work proposes a model where enhanced functional interactions between betaarr2 and receptor dimers account for the altered responsiveness of WHIM leukocytes to CXCL12 and demonstrates that CXCR4(1013) spontaneously forms heterodimers with wild-type CX CR4.
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HIV-1 entry into T-cells is not dependent on CD4 and CCR5 localization to sphingolipid-enriched, detergent-resistant, raft membrane domains.
Yann Percherancier,Bernard Lagane,Thierry Planchenault,Isabelle Staropoli,Ralf Altmeyer,Jean-Louis Virelizier,Fernando Arenzana-Seisdedos,Daniel C. Hoessli,Françoise Bachelerie +8 more
TL;DR: It is proposed that cholesterol modulates the HIV-1 entry process independently of its ability to promote raft formation, and it is shown that depleting plasma membrane cholesterol inhibits HIV- 1 entry.
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Mutation of the DRY motif reveals different structural requirements for the CC chemokine receptor 5-mediated signaling and receptor endocytosis.
Bernard Lagane,Sébastien Ballet,Thierry Planchenault,Karl Balabanian,Emmanuel Le Poul,Cédric Blanpain,Yann Percherancier,Isabelle Staropoli,Gilbert Vassart,Martin Oppermann,Marc Parmentier,Françoise Bachelerie +11 more
TL;DR: Overall, data indicate that structural requirements for CCR5-mediated activation of G proteins, albeit not involved in receptor desensitization and internalization, are needed for β-arrestin-mediated chemotaxis, which has implications for how distinct biological responses of C CR5 might rely on a different set of receptor conformations.
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CD4 and CCR5 constitutively interact at the plasma membrane of living cells: a confocal fluorescence resonance energy transfer-based approach.
Gérald Gaibelet,Thierry Planchenault,Serge Mazères,Fabrice Dumas,Fernando Arenzana-Seisdedos,André Lopez,Bernard Lagane,Françoise Bachelerie +7 more
TL;DR: An efficient fluorescence resonance energy transfer analysis is developed from experiments carried out on individual cells, revealing that receptors constitutively interact at the plasma membrane and providing evidence that this interaction takes place outside raft domains of the plasma membranes.
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