Thierry Lang
Pasteur Institute
38 Papers
520 Citations
Thierry Lang is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Antigen & Leishmania. The author has an hindex of 24, co-authored 38 publications. Previous affiliations of Thierry Lang include University of London.
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Papers
Real-Time PCR for Detection and Quantitation of Leishmania in Mouse Tissues
TL;DR: A highly accurate real-time PCR assay with which to reproducibly detect and quantify the relative Leishmania major burden in mouse tissue samples and is compatible with the clinical diagnosis of leishmaniasis.
The biogenesis and properties of the parasitophorous vacuoles that harbour Leishmania in murine macrophages
TL;DR: Improved knowledge of the parasitophorous vacuoles of protozoan parasites may help clarify how these protozoa persist in their hosts.
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Bioluminescent Leishmania expressing luciferase for rapid and high throughput screening of drugs acting on amastigote-harbouring macrophages and for quantitative real-time monitoring of parasitism features in living mice.
TL;DR: Results indicated that recombinant Leishmania can be reliably and confidently used to monitor compounds acting on intracel‐lular amastigote‐harbouring macrophages and proved that the real‐time bioluminescent assay is not only sensitive but also more rapid than culture‐base techniques.
•Journal Article
Phagocytic processing of the macrophage endoparasite, Mycobacterium avium, in comparison to phagosomes which contain Bacillus subtilis or latex beads.
TL;DR: Morphometric analysis of observations showed that the nature of the phagocytic particle affects phagosome processing: as long as particles remain undigested, maturation of phagosomes is prevented and they remain fusogenic towards early endosomes; concurrent to particle digestion, phagosom processing proceeds towards transfer of phagcytic contents to phagolysosomes which display kinetic and compositional characteristics of lysosomes.
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Disruption of the langerin/CD207 Gene Abolishes Birbeck Granules without a Marked Loss of Langerhans Cell Function
Adrien Kissenpfennig,Smina Ait-Yahia,Valérie Clair-Moninot,Hella Stössel,Edgar Badell,Yann Bordat,Joanne Pooley,Thierry Lang,Eric Prina,Isabelle Coste,Olivia Gresser,Toufic Renno,Nathalie Winter,Geneviève Milon,Ken Shortman,Nikolaus Romani,Serge Lebecque,Bernard Malissen,Sem Saeland,Patrice Douillard +19 more
TL;DR: Overall, the data indicate that langerin and BG are dispensable for a number of LC functions and should be a valuable model for further functional exploration of langersin and the role of BG.
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